His relationship with his uncle Iroh would be deeply affected. Iroh has always been a guiding figure for Zuko. If Zuko turns into a dragon, Iroh would be worried but also proud in a way. He would search for ways to help Zuko, and their relationship would become more about Iroh protecting and guiding Zuko in this new and strange form. Zuko, in turn, would rely more on his uncle's wisdom during this time.
In a fanfiction where Issei turns into a dragon, his relationships would be in flux. His relationship with his mentors or those he looks up to might change as they now see him as a different kind of being. They might treat him with more caution or more respect depending on how they view dragons. His friendships with his peers would also be altered. Some might see him as a weapon to be used in their battles or struggles, while others would see him as a friend in need of support. Romantically, if he had feelings for someone, that person would have to deal with the fact that Issei is no longer fully human. There could be jealousy from others who might want to be with the powerful dragon - Issei, or there could be newfound admiration from those who previously overlooked him.
His friends would be both amazed and a bit scared at first. Hermione would immediately start researching ways to turn him back. Ron might be more in awe of Harry's new form, but also worried about how dangerous it could be. Their dynamic would shift as they now have to protect Harry in a different way. They might also have to hide his transformation from others who could misunderstand and try to harm Harry.
With his human friends, it would be really tough. They might be scared of him at first. Astrid, for example, would be conflicted. She was attracted to Hiccup as a human, but now he's a dragon. She would have to overcome her fear and try to find a way to communicate with him. And Hiccup would feel isolated from his human friends, longing for the connection they once had.
His relationship with Sasuke could become more complex. Sasuke might be both envious of Naruto's new power and also worried about Naruto losing his humanity in the dragon form. Sakura could be initially scared but then determined to help Naruto control his form, which would strengthen their friendship. His relationship with Kakashi would change as Kakashi would now have to mentor Naruto in a different way, guiding him to use his dragon powers for good and not let them consume him.
If a character turns into a dragon, their relationships would change drastically. For example, if it was a knight who had many friends among the other knights, they would be seen as a threat once they start to transform. Their former friends might try to hunt them down out of fear. On the other hand, if it was a character who was previously an outcast, like a bastard, their new form could give them power and respect. They could form new alliances with those who seek to use a dragon's power for their own gain.
His friends would probably be initially shocked. Hermione might be a bit scared at first but then would be very interested in studying his new form. Ron would likely be in awe but also a bit jealous of Harry's new power as a dragon. Overall, their friendship would have a new dynamic as they have to adapt to Harry's different form.
Well, his relationship with Sasuke could be very interesting. Sasuke might see Naruto's fox form as a new level of power to either compete with or respect. Naruto, on the other hand, might be more protective of his friends in his fox form, which could make Sasuke question his own motives. And for his other friends like Shikamaru, he would have to come up with new strategies to work with Naruto in this new form.
At first, his Pokémon would be shocked. They've known Ash as a human trainer, and now he's this powerful psychic Pokémon. The more aggressive Pokémon in his team might see him as a threat to their position in the group. But the loyal ones, like Bulbasaur, would try to understand what happened. Ash, in his new Mewtwo form, would have to use his psychic abilities to communicate in different ways. He might be able to understand his Pokémon's thoughts more deeply, which could either strengthen or strain their relationships depending on how they all adjust.
His relationships with his sisters would likely change. For instance, his older sisters might become more motherly or more competitive in different ways. His younger sisters could look up to him even more or be jealous of the new attention he gets. With his friends, some might be more hesitant to be around him, especially if they were only used to the male Lincoln. But some friends could also be very accepting and curious about his new experience.
His relationship with Sasuke would definitely change. Sasuke might be initially shocked and confused. He might see Naruto in a new light, not just as a rival but also as someone he needs to protect. Their dynamic could shift from pure rivalry to a more complex relationship with new emotions involved.