Some of the more powerful and traditionalist factions within the DxD world, whether they be devils, angels or other species, could be antagonists. They might not like the new ideas and ways that Naruto brings from his Naruto - world, such as his more egalitarian view of power and his willingness to cross traditional boundaries. So they would try to stop him from changing things.
The devils who oppose Naruto's presence and his new - found influence in the DxD world could be main antagonists. They might see him as a threat to their power structure and the way things are done in their society.
In this kind of fanfiction, the Fallen Angels could be main antagonists. They might see Naruto and Sasuke as threats to their plans in the DxD world.
It could be an old enemy of the group who has a personal vendetta against Issei. This antagonist might be jealous of Issei's power or popularity within the group and plots to turn everyone against him. They could spread false rumors or create false evidence to make it seem like Issei has betrayed the group.
The Khaos Brigade could be a major antagonist. Their goal of causing chaos would put them at odds with Gohan's sense of justice.
The devils who oppose Gilgamesh's presence in the Highschool DxD world could be main antagonists. They might see him as a threat to their power and influence in the school.
The Sound Ninjas could be great antagonists. They could use their own unique parkour - like skills to try and stop Naruto. They might be chasing him through the forest, and Naruto has to use his parkour skills to outmaneuver them.
Maybe some corrupt officials within the prison system itself. They oppose Naruto's more humane and reform - focused approach to prison management. They might try to undermine him at every turn, for example, by cutting off resources or spreading false rumors about him among the prisoners.
Maybe a group of dark - type Pokémon that have banded together and are trying to overthrow Arceus. They view Naruto as an easy target at first, but quickly realize he is a formidable opponent with his ninja skills and new Pokémon - related powers. They would constantly try to undermine Naruto and his efforts to protect the Pokémon world.
The devils who oppose Grayfia's family could be the main antagonists. They might see Grayfia's brother - in - law as a weak link or a potential threat to their power. So they would try to get rid of him or manipulate him for their own gains.
The Hidden Leaf Village elders could be main antagonists. If Naruto turns dark because he feels betrayed by the village, they would be the ones representing the establishment he is against. Their conservative and sometimes self - serving ways could be the catalyst for Naruto's transformation, and then they would be the ones trying to stop him as he becomes a threat to their power and the village's traditional order.
The main antagonists could be the traditionalist nobles who oppose Naruto's new and inclusive ways of ruling. They might be afraid of losing their power and privilege.