One possible plot could be that Harry Potter loses his eyes in a dark magic encounter. His friends then have to help him navigate the wizarding world in a new way. Hermione might use her vast knowledge to create magical aids for him, like spells that create a sort of echolocation. Ron would be by his side, providing emotional support and physical protection when needed.
In the 'Harry Potter has no eyes' fanfiction, it could be that Voldemort curses Harry's eyes during a battle. This leads to a journey of self - discovery for Harry. He has to rely on his inner strength and the bonds he has with his friends. Neville could step up and become a more prominent figure, guiding Harry through the Hogwarts grounds that he now has to learn anew without his sight.
Perhaps in this fanfiction, Harry Potter is born without eyes. Dumbledore, seeing his potential, arranges for special magical training that focuses on his other senses. Harry then develops an extraordinary ability to sense magic around him, which helps him in his fight against Voldemort. For example, he can sense the presence of Death Eaters even before they attack, just by the feel of their dark magic in the air.