Well, her friends' reactions would vary. Quinn might be initially embarrassed, thinking it's not very cool for her sister to be in such a state. Jane, on the other hand, might see it as an opportunity to get Daria to open up even more. And some of her other friends could be a bit shocked and not know how to handle the situation at first. They might try to sober her up or just make sure she doesn't get into any trouble.
Her friends could be really surprised. They're used to a more composed Daria. They might first be concerned because she's not wearing her glasses and then realize she's drunk. Some might try to take care of her, while others could be a bit more amused at seeing this different side of her.
Well, she might act more out of character. Without her glasses, she already feels a bit disoriented perhaps, and being drunk on top of that could lead to some really clumsy situations. She could end up misidentifying people or places and getting into all sorts of comical misunderstandings.
She might be very bold. Without her glasses and drunk, she could approach Iron Man and start criticizing his suit design in a slurred voice. Iron Man would probably be both annoyed and entertained.
Well, perhaps Daria, being drunk and without her glasses, stumbles into an Avengers gathering by mistake. She could start blabbering some drunken wisdom that the Avengers find both amusing and oddly profound. Maybe she gives Captain America some off - the - wall advice on modern society, all while the other Avengers are trying to figure out who this strange, inebriated girl is.
Some of her friends might be shocked. If we consider her friends in the Inuyasha series, Sango could be very concerned and try to take care of her, making sure she doesn't do anything dangerous. Miroku, on the other hand, might initially find it a bit amusing but then also help in keeping her safe.
Arthur might be initially shocked and confused. He's used to Merlin being in control. But then he might find it quite hilarious and start teasing Merlin about it.
Her best friend might be very concerned and protective. They would try to keep her from doing anything too crazy while drunk. For example, if she tries to walk into traffic, they'd stop her.
His friends would be very concerned. Gray, for example, might try to physically stop Natsu from drinking more. Erza would likely be more gentle and try to talk to him, to make him understand that getting drunk won't bring Lucy back.
The gang would be extremely worried. Shaggy might be shaking more than usual and Scooby would be whimpering. Fred would start coming up with plans to rescue her right away, using his knowledge of traps and such.
His friends would likely be shocked and deeply concerned. Sasuke might put aside their differences and be by Naruto's side, offering his support.
One possible fanfiction could be about a girl who usually wears glasses for a shy and studious look. When she gets drunk at a party without her glasses, she becomes more carefree and bold. She might start dancing without inhibition, surprising her friends who are used to her more reserved self.