Another possibility is a crossover with the My Hero Academia world. Little Mac could be a transfer student with his boxing quirk. He'd have to navigate the hero school, compete in the sports festival, and maybe team up with Deku and the others. His boxing skills would be a unique addition to the battles against villains in that universe.
One idea could be a crossover with a popular wizarding world. The little vampire could attend a magic school and have adventures with the wizard students, facing magical creatures together. Another idea is to cross it over with a time - traveling story. The vampire travels through different eras, experiencing different cultures and historical events.
One idea could be a crossover with 'Peter Pan'. The Little Mermaid could find herself in Neverland and have adventures with Peter, Tinker Bell and the Lost Boys. Maybe she helps them against Captain Hook using her underwater skills.
There could be a little mac fanfiction where he has to face off against his own doppelganger created by an evil scientist. This doppelganger has all of Little Mac's skills but a twisted sense of morality, and Little Mac has to find a way to defeat it and restore his own reputation.
A cool plot could be a character swap. Imagine Frisk from Undertale in the world of Little Nightmares. Frisk's determination would be put to the test in the nightmarish setting of Little Nightmares. They would have to face the Janitor and the Twin Chefs just like Six does. Meanwhile, Six could be in the Underground, dealing with Flowey and Toriel. The contrast in the two worlds' aesthetics and challenges would make for an exciting story.
One idea could be that Naruto and his friends end up in the My Little Pony world. Naruto's energy and determination might be a bit of a shock to the gentle ponies at first. He could learn about the magic of friendship in Equestria, which is quite different from the chakra-based power in his own world. Maybe he'd team up with Twilight Sparkle to fight some common threat that somehow affects both their worlds, like a dark force that wants to steal both chakra and pony magic.
One interesting idea could be a crossover with "Moana". Elsa's ice powers and Moana's connection to the ocean could create a really cool dynamic. Maybe Elsa accidentally freezes part of Moana's ocean and they have to work together to fix it. Another could be with "Tangled". Rapunzel's long hair and her adventurous spirit combined with Elsa and Anna's journey in Frozen 2 would be exciting. Rapunzel could use her hair to help them climb mountains or cross chasms. A third idea is a crossover with "Beauty and the Beast". Belle's love for books and knowledge could help Elsa understand more about her powers and the history of magic in the Frozen world.
A third plot could involve a talent show at school. Mac and Daisy both want to participate but are really nervous. They help each other overcome their fears and practice their acts. Along the way, they face some competition from a mean - spirited group of students who try to sabotage their chances. But in the end, Mac and Daisy's friendship and determination see them through and they put on a great show.
One idea could be that the OC in Red Canyon discovers a hidden power within the canyon that has been forgotten by the locals. This power could be related to an ancient spirit of the land. Another plot could involve the OC forming an unlikely alliance with a group of outcasts in the canyon to protect it from a greedy corporation that wants to exploit its resources. Or perhaps the OC has a prophetic dream about a disaster that will befall the canyon and has to convince the skeptical residents to take action.
One idea could be that Dipper and Mabel end up in Equestria. Dipper might be intrigued by the magic there and start studying it, while Mabel could make friends with the ponies easily. Maybe they help the ponies solve a mystery that's been plaguing Equestria, like strange disappearances. Another idea is that a pony from Equestria somehow travels to Gravity Falls. It could be Twilight Sparkle, who is amazed by the different kind of 'weirdness' in Gravity Falls compared to Equestria.
One idea could be that the ponies discover Pokemon eggs in Equestria. They start to raise the Pokemon and learn about their powers. For example, Twilight Sparkle could study the different types of Pokemon moves using her magic knowledge.