Draco Malfoy could be another character. His interactions with Hermione would be full of tension. If Hermione is non - human, he might be even more jealous or spiteful, or perhaps he could develop a begrudging respect for her unique abilities that set her apart from ordinary witches.
Harry and Ron are often still paired with her. Even if Hermione isn't human, they are her friends and they go through adventures together. Draco might also be paired with her in some stories. If Hermione is a non - human with special powers, Draco could be intrigued by her and they could develop an unlikely friendship or more. Snape could also be involved, maybe as a mentor figure to Hermione if she is a unique magical being.
One possible plotline could be Hermione being a magical creature in disguise. Maybe she's a veela, which would add an interesting dynamic to her relationships. Her beauty would be even more alluring and it could cause some jealousy among her peers.
Professor McGonagall could also be a main character who interacts with Hermione. As a strict but fair teacher, she could guide Hermione in her studies and also in her personal growth. For example, she might give Hermione extra responsibilities or tasks that help her develop leadership skills.
There could be a human friend of Lucy, like a boy named Tom who is curious about her non - human nature and becomes her confidant. He helps her navigate the human world.
Other pureblood characters like Draco Malfoy would surely interact with her. Given her new status, Draco might be conflicted. On one hand, she's a 'mudblood' in his old view, but now as a rich pureblood, he might have to reevaluate his attitude towards her. And there could be other pureblood families' members who would either befriend or oppose her based on their family politics.
Draco Malfoy would be a likely character. Since they are in the same house now, they would have more opportunities to interact. Their relationship could start off as hostile as always, but then gradually change as Hermione shows different aspects of herself in Slytherin.
Harry and Ron are obvious choices. They have a long - standing friendship with Hermione, and their reunion would be filled with reminiscing and new adventures.
Edward could be an interesting character to pair with her. If Bella is a non - human, their relationship would take on a whole new dynamic. For example, if she's a mermaid, Edward, as a vampire, would have to deal with the differences in their species. Another good character could be Jacob. If Bella is some kind of supernatural being, Jacob's wolf nature could create a complex relationship with her, full of loyalty and conflict.
Scott is often paired with Stiles. Their friendship is a central part of the original series, and in fanfiction, it can be explored in new ways when Stiles isn't human. Scott might have to deal with the changes in Stiles and still maintain their bond.
There were many non-human protagonists in anime that were not handsome. Here are some of them: 1. Tanjiro from the movie " Ghost Blade ": Tanjiro is an ordinary teenager. His appearance is not outstanding compared to other characters, but he has a strong will and an indomitable spirit. 2. Naruto Uzumaki in Naruto: Naruto was very ordinary when he was a child. His appearance was different from other children. Later, through his own efforts and talent, he became a protagonist who received much attention. 3. Allen in the Attack of the Giant: Allen was a young boy. His appearance was somewhat different from that of a human, but he had a strong will and courage to become a protagonist who received much attention. 4. Kirito in the Sword God Realm: Kirito was an ordinary person. His appearance was not outstanding compared to other characters, but he had powerful virtual reality abilities and special abilities, becoming a protagonist that received much attention. Wei WuXian in "The Founder of the Path of Demons": Wei WuXian is a different kind of human. His appearance is a little strange compared to other characters, but he has a unique personality and charm, and became a protagonist that received much attention. The above are just a few of them. There are many other foreign protagonists in anime that are not handsome or even non-human. You can choose according to your preferences.