The Hell Girl herself could be seen as an antagonist in a sense. If she starts to see the ninja world as a place full of sinners worthy of being sent to hell without really understanding their complex situations. Naruto, who believes in the good in people, would then have to oppose her and show her that not everyone is beyond redemption.
It could be someone who misuses the power of the Hell Girl. Maybe a rogue ninja who discovers the way to summon the Hell Girl and uses her to get rid of his enemies in the ninja world. He doesn't care about the consequences or the morality of it, and Naruto has to stop him from causing more chaos.
It could be the Devil or some powerful demon lord in hell. This antagonist would try to keep Naruto trapped in hell and prevent him from escaping. He might see Naruto as a threat to his rule in hell or just enjoy tormenting him.
It could be an escaped soul from the King of Hell's domain. This soul might have a grudge against Naruto or the ninja world in general. Maybe it was wrongly imprisoned and now wants revenge by causing chaos in the living world.
It could be an ancient demon who has ruled hell for centuries. This demon might see Naruto's attempts to bring change and order to hell as a threat to his power. So, he tries to stop Naruto at every turn, using all the dark powers at his disposal like summoning hordes of hellish creatures or casting powerful curses.
One possible main antagonist could be the ruler of hell. This powerful being would see Naruto as an intruder and a threat to the order of hell. Another could be a demon who has a vendetta against Naruto for some reason, perhaps because Naruto's positive energy is anathema to the demon's evil nature.
One option could be Kaguya from the Naruto universe. Her god - like powers would pose a great threat to Bayonetta. She could be trying to expand her influence into Bayonetta's world, seeing it as a new place to conquer.
It could be a dark wizard who wants to capture the nymph for her powers. He sees the nymph's connection to nature and wants to use it to gain ultimate power in the Naruto world.
It could be a rogue ninja who has also discovered a way to harness the power of Amaterasu in a corrupt way. This ninja might want to use the power to take over the ninja villages and Naruto stands in his way.
It could be an evil ninja from Naruto's world who has somehow gained the ability to control Digimon. He wants to use this power to rule over both worlds. He targets Renamon because of her connection to Naruto and tries to break their bond. He might also be after the special powers that Naruto and Renamon possess when they work together.
It could be a rogue ninja who has a vendetta against Naruto and sees Heather as a way to get to him. Maybe this ninja was once defeated by Naruto and now wants to use Heather as bait or hurt her to break Naruto's spirit.
Perhaps a rogue ninja who has learned about the mummy's existence and wants to sell it to the highest bidder. He will stop at nothing to get the mummy, even if it means fighting Naruto and causing chaos in the process.