The main character is Clifford, the huge red dog. His human owner is always by his side in the stories and is a main character too. Then there are Clifford's fellow animal friends. There might be an old wise dog that gives Clifford advice from time to time. There could also be a group of puppies that Clifford looks after and has adventures with. These characters together create the interesting world of Clifford the Big Red Dog adventure stories.
Clifford the Big Red Dog is the central character, of course. His owner, a young boy or girl (depending on the version), plays a key role as well. There are also Clifford's friends, which may include other dogs, cats, and some friendly wild animals that he meets during his adventures. For instance, there could be a little mouse friend that Clifford protects from a mean cat. All of these characters are integral to the adventure stories.
The main character is obviously Clifford, the big red dog. His owner is also an important character. And Clifford's animal friends like the other dogs in the neighborhood are main characters too.