It could be Voldemort. He might have cast a new spell on Harry that makes him cough blood as part of his ongoing attempts to defeat Harry.
Maybe a new dark wizard or witch has emerged. They see Harry as a threat and use a strange, blood - related dark magic on him. This new antagonist could be someone who has a personal vendetta against Harry for some past deeds.
Well, perhaps it could be about Harry being injured in a battle and coughing up blood. Maybe he's in a fight with a dark wizard and gets seriously hurt.
It could be a long - lost relative of Voldemort. Maybe a distant cousin or something who has the same thirst for power and has decided to target Harry and his friends to gain more influence in the wizarding world.
Perhaps a long - lost relative of the Potter family who feels they were unjustly excluded from inheriting the manor. This relative could be jealous of Harry's status and the wealth associated with the manor. They might use dark magic to try and claim what they think is rightfully theirs, leading to a battle of magic and loyalty within the Potter family and among Harry's friends.
It could be some dark wizards who want to use the centaur's parts for potions. They might be following some ancient, dark magic recipe that requires centaur hair or hooves. So they hunt down the centaur, but Harry gets in their way.
A new dark wizard or witch could be created specifically for this fanfiction. This character could be interested in using the Huntsman's skills for their own evil purposes. If the Huntsman refuses, they become enemies. This antagonist could have powers related to dark forest magic, something that the Huntsman is familiar with but in a more malevolent form.
Voldemort could still be the main antagonist. Even if Demetri has some sort of connection or change in the fanfiction, Voldemort's overarching evil plans would still be a major threat to both Harry and Demetri, especially if Demetri tries to deviate from the Death Eaters' path.
The minotaur itself could be the main antagonist. It's a powerful and dangerous creature, and if it's been set loose in Hogwarts or is guarding something that Harry needs, it would be a major obstacle for him to overcome.
The main antagonist could be a dark wizard who has made the graveyard his lair. He uses the dark energy from the tombstones and the restless spirits there to power his dark magic. Harry stumbles upon this wizard's activities and has to stop him.
It could be a deranged fan who has found a way to bring their dark fanfiction ideas to life. This person might be jealous of the original story and wants to create chaos in the wizarding world through their fictional concepts made real.
A new dark wizard or witch could be the main antagonist. This character, jealous of Harry's fame and power, creates a situation where Harry is framed for a heinous crime. They then ensure his arrest so that they can take over the role of the 'chosen one' in the eyes of the wizarding public and start spreading their own brand of dark magic.