A great storyline might involve Parker Industries getting involved in a project to study and harness the power of a strange new energy source. Spider - Man discovers that this energy source has a connection to an ancient and powerful artifact. As he delves deeper, he uncovers a conspiracy by an old enemy who wants to use this energy and the artifact to take over the world. Meanwhile, he has to deal with the internal politics of Parker Industries, as some of the board members don't want him interfering with the company's operations.
There could be a fanfiction where Parker Industries partners with a foreign research facility. Spider - Man, being Peter Parker, is sent there to oversee the project. However, he quickly realizes that the foreign facility has some shady dealings going on. They are actually using the partnership as a cover to develop a weaponized version of Spider - Man's powers. Spider - Man has to figure out a way to stop them, all while keeping his identity a secret from the foreign agents and also ensuring that Parker Industries' reputation doesn't get ruined.