An akumatized villain could be the main character in a different kind of fanfiction. The villain was once a normal person but due to some heartbreak or injustice, they are akumatized into a dragon - like form. The story could then be about their journey of redemption or how Ladybug and Chat Noir try to bring them back to their normal self.
Maybe one of Ladybug's classmates who is also a cheerleader. For example, Alya could be a cheerleader in this fanfiction. She already has a nose for news and is friends with Ladybug, so she could use her cheerleading skills to get closer to the action and help Ladybug in a different way.
Obviously, Ladybug could be the main character. Since it's about cleaning the house, she could be shown in a more domestic side of her life, which is not often explored in the original series.
Ladybug could be the main character. Since she is the main protagonist in the original series, it would make sense for her to be in the center of this fanfiction. She could be the one to witness the car accident, or be directly involved in it somehow, like trying to stop it from happening with her powers.
Based on the title, it seems the main character could be the 'queen of mean'.
A new character could be introduced as the main villain. Maybe a corrupt police officer who turns to the dark side. He could use his knowledge of the law and the city's security systems to commit crimes and frame the Miraculous heroes. He would be a formidable opponent as he has insider knowledge.
An evil alien warlord could be the main villain. This warlord could be bent on conquering Earth and other planets in the universe. He might see the Miraculouses as a threat and try to destroy Ladybug and Chat Noir first.
Hawkmoth is an obvious choice. His whole mission is to obtain the Miraculouses, and in a death fanfiction, he could succeed in a more devious way than in the original series, directly or indirectly causing Ladybug's death.
It could be a new villain who has a power specifically related to countering the ribbon. For example, a villain who can create anti - ribbon energy that weakens Ladybug's abilities when she uses the ribbon. Maybe this villain is jealous of Ladybug's power and wants to take the ribbon for themselves to become the most powerful in Paris.
Maybe an old enemy of Ladybug or Chat Noir who sees Bluerosesnow as an easy target to get to them. They could use her as a pawn in their evil plans, trying to manipulate her into doing things that would harm the heroes. This would create a lot of conflict and drama in the fanfiction.
A possible main villain could be a character from Ladybug's past who has discovered her identity and is using that knowledge to create chaos. They could be blackmailing her or trying to steal her Miraculous by setting up elaborate mysteries and traps for her to solve.