If 'difference giver' implies something about exploring differences in a more science - fiction or fantasy context, then 'Saga' by Brian K. Vaughan and Fiona Staples is an excellent choice. It's a space - opera - like graphic novel that features a wide variety of species, each with their own unique cultures, appearances, and values. The story follows two lovers from different warring species, and in the process, it really delves into the differences between these groups and how they interact and affect each other.
Some independent graphic novels might also fit the bill. For example, 'Maus' by Art Spiegelman is a very different kind of graphic novel. It uses animals to represent different groups of people and tells a very powerful and unique story about the Holocaust. It gives a different perspective on a historical event, which could be considered as a form of 'difference giver'. Another one could be 'Persepolis' by Marjane Satrapi, which shows the differences in cultures, especially between the Western world and Iran, through the eyes of a young girl growing up in a complex political and social environment.