There could be a group of anti - hybrid fanatics. They believe that the existence of a Naruto - Ichigo descendant is an abomination that goes against the natural order of both worlds. They form a secret society and start causing chaos, trying to eliminate the descendant. Their leader could be a former ninja who lost his family in a war and blames the mixing of powers for all the world's problems. They would be a complex antagonist as they have their own warped ideology to drive their actions.
It could be a powerful ninja who has become corrupted by the idea of the descendant's powers. He wants to steal those powers for himself to gain ultimate control over the ninja world. Maybe he has a deep - seated envy of the unique combination of abilities the descendant has.
It could be a rogue ninja who wants to use the descendant for their own power - gain. Maybe someone who believes that by controlling the descendant, they can access Kaguya's ultimate power. For example, a power - hungry ninja who has been researching Kaguya's secrets for a long time.
It could be a rogue ninja who wants to steal the power of the descendant. This ninja might believe that by obtaining the Hamura - related powers, they can rule the ninja world.
It could be a powerful ninja who is jealous of the descendant's unique powers. This ninja might see the combination of Naruto - like abilities and Moka - related traits as a threat to their own status in the ninja world and thus tries to eliminate the descendant.
Another possibility is a group of ninja from a rival village. They fear the power that Naruto might gain from his Raizen heritage and decide to take preemptive action. They could be led by a power - hungry shinobi who believes that by eliminating Naruto, they can prevent the Hidden Leaf Village from becoming too powerful. So, they send their best assassins and warriors after Naruto.
It could be a rogue Uchiha who feels threatened by the descendant's claim to Izuna's legacy. This Uchiha might think that the descendant is unworthy or that they are trying to steal the spotlight from the main Uchiha line.
The main antagonist could be a power - hungry shinobi within the same village as the descendant. This shinobi believes that they are more worthy of Hashirama's power and legacy. So, they scheme behind the scenes to undermine the descendant, spread false rumors about them, and even try to set up situations where the descendant would lose their life so that they can claim the power for themselves.
There could be a group of corrupted Quincy who view Ichigo's resurrection as an abomination. They believe that his power goes against the natural order of things. So, they band together to try and eliminate him. They might have some new and dangerous weapons or techniques specifically designed to counter Ichigo's resurrected powers. This group could be led by a very powerful Quincy who has a personal vendetta against Ichigo or the Soul Reapers in general.
Perhaps a vampire scientist who is conducting unethical experiments on both humans and vampires. Ichigo gets in his way when he discovers what the scientist is doing. This antagonist could be using his scientific knowledge to create powerful and dangerous hybrids. He believes that he is creating a new and better vampire - human world order, but his methods are causing a lot of harm, and Ichigo is determined to stop him.
A powerful sorcerer could be the main antagonist. This sorcerer might be after the same power source that Ichigo and Jackie are either protecting or trying to use for good. The sorcerer could be using dark magic to create chaos in their world and trying to stop Ichigo and Jackie from achieving their goals.