Regarding the relationship with the other houses, the older brother could be a Hufflepuff or a Ravenclaw. If he was a Hufflepuff, it might make the Hufflepuffs more friendly towards Harry as they would see him as related to one of their own. If he was a Ravenclaw, the Ravenclaws might expect Harry to be as intelligent as his brother, which could lead to some interesting interactions and challenges for Harry at Hogwarts.
It would likely change the power dynamic. The sister could be a popular and powerful figure at Hogwarts. She might be in a different house than Harry, which could lead to some friendly rivalries between the houses in a different way. For example, if she was in Slytherin, there could be more cooperation between Gryffindor and Slytherin because of their family bond.
His presence could make Harry more protective. Harry might be more cautious in his adventures, not wanting to put his little brother in danger. For example, when dealing with the Marauder's Map, he might be more hesitant to use it if he thinks it could expose his brother to trouble. Also, his friends like Ron and Hermione would have to adjust to having a younger, perhaps more inexperienced, person around. They might feel responsible for him as well.
It would likely make his relationship with Hermione more strained at first. Since Hermione is very rule - abiding and a Basilisk is a dangerous creature. She might be constantly worried about the safety of the other students. Ron, on the other hand, might be both scared and a bit in awe. He would be more hesitant around Harry. But some students like the Weasley twins might be really excited and want to learn more about the Basilisk, which could bring Harry closer to them in a different way.
At Hogwarts, Harry would have someone to look up to within his family. This could boost his self - esteem. His older brother could be popular, and through that, Harry might gain more friends. Also, they could team up in Quidditch, making Gryffindor's team even stronger.
His relationship with the Dursleys might be more complex. They could be even more cruel, seeing him as a burden because of his cancer. Or, in a different take, they might feel a bit of pity and be slightly less horrible. As for his friends at Hogwarts, he might be more guarded at first. He has been through a tough time with his health, so it could take him longer to open up to Ron and Hermione.
His friends might be initially shocked but then find it hilarious. Ron would probably tease him good - naturedly. Hermione, on the other hand, would be more concerned about how to reverse it at first but then accept it as part of Harry's new look. Some of his Slytherin rivals might use it as an excuse to taunt him more, thinking he looks ridiculous.
Godric Gryffindor's view might not change much. He'd still see Hogwarts as a place to foster courage, but he might gain new insights from the fanfiction about how students in modern - day interpretations uphold that value. Salazar Slytherin could become more cynical. If he saw his house being misrepresented in some fanfictions as all - evil, he might think Hogwarts has strayed from his original intentions. Helga Hufflepuff would probably feel more positive. The fanfiction that emphasizes kindness and hard work would make her believe Hogwarts is still a great place for nurturing good values. Rowena Ravenclaw might be more open - minded. She'd see different perspectives on Hogwarts in the fanfiction and might consider new ways of teaching and learning in her view of the school.
The story would be drastically different. Without Harry, there's no Boy - Who - Lived to be the main antagonist to Voldemort. Hogwarts might not be the safe haven it was in the original series. Voldemort could target the school more directly, and the students would live in constant fear.
It could make Hermione more confident. Knowing she has an older brother might give her a sense of security, so she could be more assertive in her friendships. For example, she might be more likely to stand up to Ron when they have an argument, because she has that family support in the back of her mind.
Well, he'd probably be more of a legacy student. He might be treated with even more respect or envy from the start. And he could have a different group of friends. Instead of Ron and Hermione, he might be closer to his brother's old gang, like Sirius and Remus, from the very beginning at Hogwarts.