Kakashi might be involved too. As a sensei, he has a responsibility to protect the village's secrets. So, if the Forbidden Scroll is in danger, he would be right in the middle of the action. Also, his own knowledge of jutsus and the village's history could play a crucial role in any story involving the scroll.
Naruto is often a main character. Since he has a knack for getting into trouble and his determination to become stronger, he's likely to be involved with the Forbidden Scroll in some way. He might be the one who accidentally discovers it or has to protect it.
Sasuke could also be a main character. His thirst for power and his own secrets might draw him to the Forbidden Scroll. He could be seeking a particular jutsu within it to help him achieve his goals, whether it's revenge or something else.