Sure. In the real story of the Painkiller series, a significant element could be the different types of pain shown. There could be emotional pain, such as loss and betrayal, and physical pain. Also, the ways in which the characters try to numb or overcome the pain, perhaps through substances or self - discovery, are important elements. The setting might also play a role, as it could either enhance or mitigate the pain experienced by the characters.
One key element could be the concept of pain itself. It's likely a central focus that drives the plot. Another might be the characters' relationships with pain, like how they resist or succumb to it.