A human anti - mutant organization's leader could be the main antagonist. He might view Nightcrawler and Azazel as a threat to the 'purity' of the human race and would do anything to capture or kill them. This would force Azazel and Nightcrawler to fight not only for their own survival but also for the future of mutants in general.
It could be a powerful mutant who wants to use Nightcrawler's teleportation abilities for his own evil purposes. He might see Nightcrawler as a key to achieving some sort of world - domination plan.
Another option is a demon from Azazel's past. This demon could be after Azazel and sees Nightcrawler as a way to get to him. Maybe the demon has a grudge against Azazel and will stop at nothing to destroy him, and by extension, Nightcrawler who is now associated with Azazel.
One idea could be that Azazel reveals a long - hidden family secret to Nightcrawler. Maybe something about their heritage that Nightcrawler was never aware of. This could lead to Nightcrawler having to make some difficult decisions regarding his identity and his place in the world.
Well, I really liked 'The Unseen Bond' fanfic about azazel and nightcrawler. It focuses on the emotional side of their relationship. It shows how Nightcrawler struggles with the fact that Azazel is his father. And then there's 'Azazel's Redemption Arc' which is quite unique. It gives Azazel a chance to redeem himself through his relationship with Nightcrawler. Also, 'Nightcrawler's Journey with Azazel' is a good read as it takes the two on an adventure together.
It could be a powerful warlock who has found a way to manipulate time and space. He wants to stop Paige and Prue from joining forces because he fears their combined power. So he creates various obstacles and illusions to keep them apart.
Maybe a powerful rogue ninja who has discovered a way to steal the powers of divine entities. He sets his sights on Amaterasu and Naruto because he knows that if he can combine their powers, he will be unstoppable. He creates various traps and illusions to separate them and weaken them so that he can carry out his evil plan.
A powerful new pirate group could be the main antagonist. They might be after the same treasure or territory as Luffy and Shanks. They could have some unique and dangerous abilities, like the ability to control sea monsters. Their leader could be a former crewmate of a well - known and feared pirate, who has his own vendetta against both Luffy and Shanks for some past reasons.
There could be an ancient force that is awakened by the meeting of Harry and Hela. This force wants to destroy both of them because their combined powers could potentially stop it from achieving its goal of spreading chaos and destruction throughout all the realms. It would use all kinds of devious means to try and separate them and defeat them one by one.
Maybe a powerful warlord from Negan's world who somehow follows him into Artemis' realm. This warlord, with his own thirst for power and destruction, would oppose both Negan (if he starts to side with Artemis) and Artemis herself, wanting to take over the new world he has found.
It could be another god who is jealous of Zeus' interest in Atreus. Maybe a god who feels that Atreus is an outsider and doesn't belong in their divine affairs.
Another possibility is that Death is being controlled or influenced by a greater cosmic entity. In this case, that entity could be the main antagonist. It uses Death as a tool to test or destroy the Avengers. The Avengers would then have to not only deal with Death but also find a way to face this more powerful and mysterious entity behind Death's actions.
Kingpin could be a great antagonist. He has a long history with Daredevil and his presence in Hell's Kitchen could draw Peter in. His criminal empire and power would pose a significant threat to both heroes.