The ponies in Ponyville would also show concern. The little ponies who often play with Spike would be sad and bring him little gifts like flowers or their favorite sweets. The older ponies would offer their wisdom on how to heal and take care of Spike. Overall, Spike getting hurt would create a wave of worry, care, and unity among the characters in the MLP world.
The rest of the Mane 6 would also be very affected. Rainbow Dash, for instance, would be angry at whatever or whoever caused Spike to get hurt. She would be eager to take action and get revenge if it was another character's fault. Pinkie Pie would be sad and would try to cheer Spike up with her parties and jokes, but deep down she would be really concerned. Rarity would fuss over Spike, trying to make him as comfortable as possible and using her sewing skills to make bandages or something to help with his injuries.
Twilight Sparkle would likely be extremely worried. Since she raised Spike, she would feel a deep sense of guilt, as if she failed to protect him. She might even blame herself for putting Spike in a situation where he could get hurt in the first place. She would probably rush to find a way to heal him, using all of her magic knowledge.