Well, in some 'Harry Potter and the Prophecy' fanfiction, a plot twist could be that the prophecy was not a prophecy at all but a spell cast by an ancient wizard to set in motion a series of events for a greater purpose. For example, it was to bring about a new era of magic where Muggle - borns and pure - bloods could co - exist peacefully. This would completely change the way the characters view the prophecy and their roles in it. Also, the prophecy might be tied to a different character than Harry or Voldemort, like a minor character who suddenly becomes central to the whole story.
Another concept is the idea of prophecies being manipulated. In some fanfictions, dark wizards or witches try to change the outcome of the prophecy by interfering with the events or people involved. This can create a lot of tension and drama as the characters fight against this manipulation.
One interesting plot twist could be that Harry discovers he has the ability to communicate with the Basilisk on a deeper level than just Parseltongue. Maybe he can see through the Basilisk's eyes and use this to his advantage in uncovering secrets within Hogwarts that even Dumbledore doesn't know. Another could be that the Basilisk is not truly a villain but was being controlled by a dark force all along, and Harry has to find a way to break that control and free the Basilisk.
One interesting plot twist could be that the basilisk has an unexpected alliance. Maybe it teams up with a group of outcast magical creatures to take revenge on those who have wronged them. This would completely change the dynamic as in the original, the basilisk is mainly a tool of Voldemort.
In this fanfiction, a great plot twist might be that the gamer's knowledge of game strategies is used to outwit Voldemort in a completely unexpected way. Instead of a traditional magical duel, the gamer uses their understanding of leveling up and collecting power - ups to somehow weaken Voldemort's magic. Maybe they find a way to 'hack' into his dark magic, using skills from the game world that no one in the wizarding world had thought of before.
One interesting plot twist could be that instead of Ron leaving and coming back, Hermione actually leaves the group for a while because she discovers a dark secret about her family's past that she needs to figure out on her own. This would add a whole new layer of drama to the story.
Well, one possible plot twist could be a revelation about a character's true heritage that was hidden all along. For example, a minor character might turn out to be related to one of the major wizarding families in ways no one expected.
One interesting plotline could be how Harry finally masters all the skills he needs to fulfill the prophecy in a really unique way. Maybe he discovers a new spell or a hidden power within himself.
One interesting plot twist could be that a minor character in the original series turns out to be a key figure in the fanfiction's plot. For example, a seemingly unimportant Hogwarts student might be revealed as a powerful wizard with a hidden agenda that affects Harry and his friends.
One interesting plot twist could be that instead of Cedric Diggory being the Hogwarts champion, Neville Longbottom is chosen by the Goblet of Fire. This would completely change Neville's character arc in this part of the story, as he'd have to face much more danger and scrutiny. It could also lead to new friendships and rivalries.
A really cool plot twist in some fanfictions is that Harry actually has a long - lost sister. This sister could be hidden away by some powerful magic for her protection. Her appearance in the Deathly Hallows time frame would throw everything into chaos as she might have her own ideas about how to deal with Voldemort and the Deathly Hallows.