Iruka sensei would be a bit more understanding. He would see Wendy's crush as a normal part of growing up. He might encourage Wendy to be honest with her feelings but also remind her to respect Naruto's space and his own goals as a ninja. Hinata might be empathetic towards Wendy. Since she also had feelings for Naruto, she could give Wendy some advice on how to handle her crush in a more appropriate way. The villagers might gossip about Wendy's crush, which could put some pressure on Wendy and Naruto.
Shikamaru would likely find the whole situation tiresome. He might think it's a bother and wonder why Wendy has to have a crush on Naruto. Sasuke would probably be indifferent at first. He has his own goals and isn't really interested in Naruto's love life. However, if Wendy's crush starts to interfere with Naruto's progress in some way, Sasuke might step in and tell her to back off. Naruto's friends like Choji and Kiba would probably tease Naruto about Wendy having a crush on him, which could make Naruto a bit embarrassed.
Sakura might be initially shocked but then she would be determined to help Naruto find out what's wrong. She could start researching in the hospital's library for any medical or historical records related to such a phenomenon.
Hinata might be a bit surprised at first. Since she also has feelings for Naruto, she could feel a bit of jealousy. But being the kind person she is, she would probably try to be understanding and not let it affect her friendship with Hanabi.
Sakura would be very concerned. She has known Naruto for a long time and has seen his growth. She would probably try to be there for him, using her medical skills to make sure he's physically okay and offering emotional support. For instance, she might sit by his side and talk to him about his feelings, just like she did when they were younger.
If Naruto does figure it out, he could be really flattered. He might see Anko in a whole new light. But he would also be a bit confused because he has always seen her more as a senior or a friend. He would probably try to handle the situation gently, not wanting to hurt her feelings.
Naruto, being the friendly and optimistic one, would likely be excited for Gaara. He might encourage Gaara to be more open about his feelings towards Sakura. He could offer advice based on his own experiences with Hinata. Sasuke, though, would probably be aloof. He has always been more focused on his own goals and revenge. He might view Gaara's crush as a distraction for Gaara and tell him to focus on more important things, like protecting his village. However, deep down, he might also hope that Gaara can find some happiness.
Sasuke might be a bit taken aback at first. He's used to Naruto's normal look, and this change could make Sasuke see Naruto in a new light, perhaps as a more formidable opponent or an even stranger ally. Sakura would probably be shocked too. She might tease Naruto about it at first but then grow to accept it. Kakashi would likely raise an eyebrow and make a comment about how Naruto is always full of surprises with his new look.
Sasuke would probably be in denial at first. He has always seen Naruto as a rival and a strong force. But once he accepted the reality, he would do whatever it takes to help, maybe even going on dangerous missions to find a cure. He would also feel a sense of guilt if he had ever underestimated Naruto because of the disease.
Sakura might be initially shocked and then start laughing uncontrollably. She would probably tease Naruto about it for a while. Sasuke, on the other hand, would likely just give a slightly raised eyebrow and then act as if it's not a big deal, but deep down he might be a bit amused. Kakashi would probably make a dry joke about it.
Naruto might become more attuned to the magical aspects of Wendy's world. His usually brash and straightforward ninja style could be tempered with Wendy's more gentle and magical approach. Wendy, in turn, could gain some of Naruto's boldness. She might become more confident in taking risks, like Naruto does when facing powerful enemies in his world.
Sakura would be very worried and immediately start taking care of Naruto. She would check his temperature, give him medicine, and make sure he's comfortable. Kakashi might be a bit more laid - back on the outside but would secretly be concerned. He would keep an eye on Naruto's condition and also ensure that the village is still protected. Sasuke, if he's around, might act like he doesn't care much at first, but he would actually be worried. He might even go on a little side - quest to find a special herb or something that could help Naruto get better faster.