Another option is that the antagonist is an entity that is trapped inside the book. When Naruto finds the book, this entity sees it as a chance to escape and cause chaos in the ninja world. It would then try to manipulate Naruto into freeing it, and when Naruto realizes what's going on, he has to fight against this entity to keep the ninja world safe.
There's a possibility that the antagonist is the creator of the book. This person might not want Naruto to have the book for some dark reasons. For instance, the creator could be planning something evil with the book and Naruto's interference would ruin his plans. So he tries to stop Naruto from using the book or even tries to take it back.
It could be someone who also wants the magic book. Maybe a rogue ninja who believes the power in the book can make him the most powerful in the world.
In this fanfiction, Naruto might use the magic book to gain new powers. Maybe the book contains spells that can enhance his jutsu.
Perhaps there's a group of hunters in the fanfic. They don't care about the wolf pup's connection with Naruto. All they see is a valuable catch. They might try to set traps for the pup and Naruto would have to outwit them to keep the pup safe. They could be motivated by money or a desire to prove themselves as the best hunters in the area.
It could be a passionate Potterhead who has a great imagination for creating new adventures for Harry. There are many fans out there who love to write their own take on the Harry Potter universe.
It could be Orochimaru. He might have found a way to enter the Grand Magic Games world and is using his dark jutsu to control some of the magic users. He wants to use the power of the games to become even more powerful and immortal.
Maybe a new, unknown character. This character could be from a long - lost clan that has a connection to the Book of Life. They believe that the book should be used in a way that Naruto and the other ninjas don't agree with, like using it to rule over all the ninja villages.
In this fanfiction, the main antagonist could be an ancient evil that has been trapped within the grimoire. Once Harry finds the grimoire, this evil starts to gain power and tries to use Harry to break free completely and spread chaos in the wizarding world.
The book could be about the history of the ninja clans. Maybe it contains long - lost secrets of the Uchiha or Senju clans. It might detail their ancient jutsus, alliances, and feuds.
It could be a dark wizard who wants to get his hands on the lightsaber for its power. He might see it as a new tool to use in his evil plans, like using it to break into Gringotts or to fight off any who oppose him.
It could be a dark wizard who also has an interest in the snake. Maybe he wants to use the snake's powers for evil purposes, like opening a portal to a dark dimension or controlling other magical creatures. So he becomes the main obstacle for Harry as he tries to protect the snake.
Well, it could be that the magic book is sentient and starts to communicate with Harry. It could offer him advice on how to defeat Voldemort in a completely new way, like revealing a long - forgotten prophecy.