Another interesting plot could be that the OC is an outcast in their world, and Greed takes an interest in them. He sees potential in their unique situation and tries to use them to gain more power, but the OC ends up changing Greed's view on things through their friendship.
Maybe a story where the OC is a powerful being that Greed tries to manipulate into working for him. The OC, being smart, plays along at first but then turns the tables on Greed, teaching him a lesson about true power not being just about possessions.
The plot could involve the OC being a alchemist on a quest for a powerful alchemy item. Greed, sensing an opportunity for himself, joins the OC. Along the way, they encounter various enemies and obstacles. For instance, they might have to face off against other homunculi who don't want Greed interfering in their plans. The relationship between Greed and the OC could start off as a simple partnership but evolve into a deep friendship or more as they rely on each other to survive.
One idea could be a Garou OC who is a lone wolf, not part of any pack, and has to survive in a world full of both human and supernatural threats. They could have unique powers like the ability to blend into shadows, which helps them in their solitary existence.
One idea could be to explore Imhotep's life before he became the mummy. Maybe he was a brilliant architect with a secret love interest that influenced his actions later. Another could be a story where an OC helps Imhotep break free from his curse in a different way than in the movies. For example, the OC has a special magical ability that can nullify the dark magic binding him.
Well, you could write a fanfiction about a Marvel OC who is from an alternate dimension where the roles of heroes and villains are reversed. This OC comes to the main Marvel universe to try and right the wrongs in their own dimension. Or perhaps an OC who is a young Asgardian with a gift for magic that Odin tries to keep hidden for some reason, and the OC has to navigate the politics of Asgard while also dealing with their emerging powers.
One idea could be an OC who is a spy sent to infiltrate Doflamingo's organization. This OC could have a hidden past that slowly gets revealed as they gain Doflamingo's trust. Another idea is an OC with a special power that Doflamingo wants to control or use for his own evil plans. For example, the OC might be able to manipulate time in a small area, which could be a great asset in battles or heists.
Another interesting concept is to create an arrancar OC who is an outcast among their kind. Maybe they have a unique power or appearance that makes the other arrancars shun them, and they have to find their place in the world.
You could write a fanfiction where your OC is a mutant with a unique power that Logan is initially skeptical of. As they interact more, Logan realizes the potential of this new power and they work together to fight a common enemy. For example, if your OC can manipulate time on a small scale, it could add an interesting dynamic to their adventures.
One idea could be to create an OC who is a new transfer student at the school in Majikoi. This OC could have a unique skill, like being a martial arts expert from a far - off land. They would then get involved in the various clubs and rivalries at the school.
One idea could be creating an OC who has the power of music in the Precure world. They could use melodies to heal and fight against the villains. Another is an OC from a different dimension who stumbles into the Precure universe and has to learn their ways to help. And also, an OC that is a hybrid of a magical creature and a human in the Precure world, bringing unique powers and a fresh perspective to the story.
One idea could be creating an OC who is a long - lost relative of a main character. For example, an OC could be Natsu's sister who was separated from him at a young age. This OC could have unique fire - based magic that is different from Natsu's. Another idea is an OC from a different dimension that gets trapped in the Fairytail world. They could bring new types of magic and technology from their own world, causing chaos and new adventures.