In the book, the setting might be described in more detail in terms of the inner thoughts of the characters regarding the environment. For example, the way the polluted city is perceived by the protagonist at a psychological level. While in the movie, the visual setting is more focused on creating a dystopian, neon - lit cityscape with a lot of Asian - influenced architecture. It's a more immediate visual impact compared to the written description in the book.
The book may have a setting that is more open to the reader's imagination. Since words can create a broader range of mental images. However, the Blade Runner movie has a very specific and iconic setting. The movie's setting is highly stylized with its dark, rainy, and overcrowded city streets. The book might have different areas of focus in the setting, perhaps more on the outskirts or the less - explored parts of the world it creates, while the movie is centered on the bustling, chaotic core of the city.