One possible plotline could be Naruto feeling extremely lost and having to find his own way to become stronger without their guidance. He might start to question his own worth and abilities, but then he could meet new allies who help him realize his true potential on his own. For example, he could encounter some other outcast ninja who have their own unique skills and together they form a new kind of ninja team that challenges the traditional ways of the ninja world.
Another plot could be that Naruto goes on a journey to find Tsunade and Jiraiya to understand why they abandoned him. Along the way, he discovers secrets about his parents and their relationship with Tsunade and Jiraiya. This could lead to him uncovering a bigger conspiracy in the ninja world that was the reason behind their actions. Maybe it has something to do with an ancient prophecy or a power struggle within the hidden villages.