Perhaps a group of pure - blood supremacists could be the main antagonists. They see the Peverell descendant as a threat to their ideas of a pure - blood - only wizarding world. They might try to undermine the descendant at every turn, spreading false rumors and trying to isolate them from the rest of the wizarding community.
The main antagonist could be an ancient evil that was once defeated by the Peverells. Now that a descendant has emerged, it awakens to seek revenge. This evil entity could be very powerful and manipulative, using other wizards as pawns to get to the descendant. It might also try to corrupt the descendant's mind, making them doubt their own goodness and the value of their heritage.
One possible plot could be that the descendant discovers a hidden power within them related to the Peverell heritage. Maybe they find an ancient artifact that only a Peverell can unlock, leading them on a dangerous adventure to protect it from dark wizards who want to use it for evil.
Another option is that the antagonist is an ancient magical being that has been awakened by Harry Peverell's time - traveling disruptions. This being, which was once in a slumber, now sees Harry as an intruder in the timeline and wants to restore the order of things by getting rid of him. It could have powers that are not well - known in the modern wizarding world, making it a very difficult enemy to defeat.
It could be a descendant of a rival family to the Peverells. This person might be jealous of the power and secrets that the Peverell family held and wants to stop Harry from uncovering them. They could try to manipulate events to their advantage and create obstacles for Harry.
Perhaps an ancient evil that Gryffindor once sealed away is starting to break free. This entity sees the descendant as a threat because they have the potential to reseal it. So, it tries to corrupt the descendant or stop them in any way possible.
It could be a powerful ninja who has become corrupted by the idea of the descendant's powers. He wants to steal those powers for himself to gain ultimate control over the ninja world. Maybe he has a deep - seated envy of the unique combination of abilities the descendant has.
It could be a rogue ninja who wants to use the descendant for their own power - gain. Maybe someone who believes that by controlling the descendant, they can access Kaguya's ultimate power. For example, a power - hungry ninja who has been researching Kaguya's secrets for a long time.
It could be a rogue ninja who wants to steal the power of the descendant. This ninja might believe that by obtaining the Hamura - related powers, they can rule the ninja world.
It could be a powerful ninja who is jealous of the descendant's unique powers. This ninja might see the combination of Naruto - like abilities and Moka - related traits as a threat to their own status in the ninja world and thus tries to eliminate the descendant.
Another possibility is a group of ninja from a rival village. They fear the power that Naruto might gain from his Raizen heritage and decide to take preemptive action. They could be led by a power - hungry shinobi who believes that by eliminating Naruto, they can prevent the Hidden Leaf Village from becoming too powerful. So, they send their best assassins and warriors after Naruto.
It could be a rogue Uchiha who feels threatened by the descendant's claim to Izuna's legacy. This Uchiha might think that the descendant is unworthy or that they are trying to steal the spotlight from the main Uchiha line.