Hermione's friends from Hogwarts, like Neville, would be very surprised. Neville might be a bit hesitant at first but would ultimately respect Hermione's decision. The other Gryffindors would likely be whispering and gossiping. For Draco's part, his family, especially his parents, would have a complex reaction. His mother might be more understanding as she has shown some signs of having a softer side. His father, however, would probably be angry at first, seeing it as a break from their pure - blood traditions.
The Weasley family in general would be quite divided. Some of the older Weasleys might be more traditional and disapprove, thinking that Hermione could have done better. But the younger Weasleys like Luna might be more accepting. Luna has always been open to different ideas and relationships. As for Draco's friends, they might also be shocked. Some of his Slytherin friends might feel betrayed that he has married a Gryffindor, while others might see it as a bold and interesting move.