Darth Vader could be a great main antagonist. His power in the Force and his imposing presence would be a huge threat to The Flash. He could try to capture The Flash to study his speed abilities for the Empire.
Maybe General Grievous. His multiple limbs and combat skills, combined with his droid army, would pose a serious challenge to The Flash. He might see The Flash as a new and interesting target to add to his collection of Jedi kills.
The Emperor could also be the main antagonist. He could sense the power of the speed force within The Flash and want to corrupt it for his own use. He could use his Sith mind tricks on The Flash and try to turn him against his new Star Wars allies, creating a complex and dangerous situation for everyone involved.
The main antagonist could be a rogue Imperial officer who has his own agenda. He's tired of following the Emperor's orders and decides to create his own power base. He targets Delta Squad because they keep getting in the way of his plans to steal valuable resources and technology from various planets.
The Riddler could be a great main antagonist. He could create puzzles and traps that are based on both the Flash's speed and Gotham's dark secrets. For example, he might set up a trap where the Flash has to run through a maze of moving walls in Gotham while also solving riddles that are related to Batman's past.
The Reverse - Flash would be a great antagonist. His time - traveling abilities and his vendetta against the Flash family could make for a really intense story, especially if he teams up with other villains from the Kid Flash's universe in a crossover.
Perhaps a rogue demigod who has made a deal with a speed - based meta - human villain from the Flash's world. Together, they plan to take over both the magical realm and Central City. The demigod could use his powers in combination with the meta - human's technology to create some really tough challenges for Percy and the Flash.
Well, perhaps there could be a situation where the Force in the Star Wars world interacts with The Flash's speed force. For example, some Sith Lords could try to harness the speed force for their own dark purposes, and The Flash has to team up with the rebels to stop them. He could also teach some of the Jedi his unique way of moving super fast, which could give them an edge in combat.
It could be a rogue Sith Lord who has broken away from the traditional Sith teachings and is causing destruction in his own way. He might not be interested in the age - old battle between the Sith and the Jedi but just wants to spread chaos for his own reasons.
Perhaps an ancient evil force that Darth Vectivus accidentally awakens. This force is much more powerful than him and starts to control him, making him do things he doesn't really want to. Now Darth Vectivus has to find a way to break free from this new master while also dealing with the rest of the galaxy that sees him as the bad guy.
The Riddler could be a great main antagonist. He could use his intellect to create puzzles and traps that not only challenge Batman's detective skills but also the Flash's speed. For example, he could set up a series of time - locked puzzles where the Flash has to use his speed in a very specific way at specific times to unlock them, while Batman has to figure out the overall pattern of the puzzles.
The main antagonist could be a powerful Sith Lord. This Sith Lord might see the rogue knight as a threat to their plans for galactic domination. Since the rogue knight is operating outside the normal Jedi - Sith conflict, the Sith Lord would want to eliminate this unpredictable element.
Darth Maul could be a great antagonist. His double - bladed lightsaber would be a formidable weapon against Naruto. Maul's acrobatic fighting style and his Sith powers would pose a huge challenge to Naruto's ninja skills and new - found Jedi powers.