The antagonists could be forces of dark magic. They might sense the power within the baby and want to either corrupt it or use it for their own evil purposes. For example, there could be a sorcerer who wants to steal the baby and raise it to be his minion. Also, some neighboring kingdoms that see Camelot's new heir as a future threat might send spies or assassins to target the baby.
Maybe there are some secret organizations that want to study the baby because it's a hybrid of Ben and Gwen's powers. These organizations might not have evil intentions at first, but their methods of trying to get the baby could make them antagonists as they go against Ben and Gwen's wishes to protect their child.
One possible plot could be that Arthur and Gwen face challenges in raising their baby in a world filled with political intrigue. Maybe there are those who see the baby as a threat or a tool for power. For example, some nobles might try to use the baby's influence to gain more land or favors. Arthur and Gwen would then have to protect their child while also ruling Camelot fairly.
In a fanfiction, it could be that an evil sorcerer casts a spell on Gwen and Arthur's unborn baby. The baby starts to show strange and dangerous symptoms. Merlin is the only one who can sense what's really wrong. He has to race against time to break the spell. He delves deep into his magic knowledge and also consults ancient magical texts. Along the way, he has to hide his actions from those in Camelot who still distrust magic, all while trying to save the baby and ensure the future of Camelot's royal family.
In this fanfiction, there might be some werewolves who view the baby as an abomination since it's part vampire. They could try to harm the baby, which would put Bella and Stefan in a difficult position to defend their child.
The Volturi could be antagonists. In the Twilight universe, they are the powerful vampire coven that enforces vampire laws. They might see the baby as a threat to their power or a violation of their rules. They could try to eliminate the baby or control Bella, Edward, and their family.
One possible antagonist could be an evil scientist who wants to study the baby's unique genetic makeup. Since Shadow and Blaze are both special characters, their baby would likely have an interesting genetic combination that the scientist could use for his own malicious purposes.
Maybe an old acquaintance from their past who has a grudge against them. This person could spread rumors about them being unfit parents just because they are in a same - sex relationship. And that would create a lot of problems for Emily and Alison as they prepare for the baby.
It could be Bowser. He might see the new baby as a way to get to Daisy and Luigi. He could try to kidnap the baby to use as leverage against them.
It could be some of the traditional antagonists from the original story, like the Volturi. They might see the baby as a threat to their power or the order they've established in the vampire world.
The other gods who oppose the union of a mortal (or demigod in Percy's case) and a goddess could be antagonists. They might see the baby as an abomination or a threat to the order of the divine world. For example, some of the more traditional and strict gods could try to harm the baby or separate Percy and Hestia.