Danzo could be a great antagonist in this 'naruto highschool au fanfiction'. He could be the strict school principal who enforces very strict rules and has a hidden agenda. He might not like Naruto's free - spirited nature and try to expel him. Also, Kabuto could be a student who is under Danzo's influence and causes trouble for Naruto and his friends.
One possible main antagonist could be Itachi. He could be an older student who is a genius and seems perfect on the outside. But secretly, he is working on some plan that could harm the school. He might see Naruto as a threat to his plans because Naruto has a way of uniting people. And then there's also Hidan, a delinquent student who just likes to cause chaos and is often at odds with Naruto.
Sasuke could still be an antagonist in a way. Maybe in this AU, he's more dismissive of the female Naruto because of his own ideas about strength and gender. He might see her as weak at first and that could create a lot of tension between them.
The devils who oppose Gilgamesh's presence in the Highschool DxD world could be main antagonists. They might see him as a threat to their power and influence in the school.
Alois could be a main antagonist. In a high school setting, he might be the jealous rival of Ciel. He could try to undermine Ciel's position as student council president or spread rumors about him. His butler, Claude, would be helping him with his devious plans.
If we swap Star and Marco, then the main antagonists could be those who were previously minor annoyances for the other character. For example, if Marco is now in Star's role, Ludo, who was a main antagonist for Star, could be an even bigger threat as Marco might not have Star's natural magical intuition to deal with him.
I think Moon could be a great main character. She's independent and strong - willed. In the high school au, she could be the one who challenges the traditional Pokémon training methods at school. Then there's Sun, who could be her rival or partner, depending on how the story goes. There could also be some original characters created specifically for this fanfiction. For example, a new student from a far - off region who has unique Pokémon from places not seen in the original Sun and Moon games, adding a fresh perspective to the high school's Pokémon scene.
The Sound Ninjas could be great antagonists. They could use their own unique parkour - like skills to try and stop Naruto. They might be chasing him through the forest, and Naruto has to use his parkour skills to outmaneuver them.
Maybe some corrupt officials within the prison system itself. They oppose Naruto's more humane and reform - focused approach to prison management. They might try to undermine him at every turn, for example, by cutting off resources or spreading false rumors about him among the prisoners.
Maybe a group of dark - type Pokémon that have banded together and are trying to overthrow Arceus. They view Naruto as an easy target at first, but quickly realize he is a formidable opponent with his ninja skills and new Pokémon - related powers. They would constantly try to undermine Naruto and his efforts to protect the Pokémon world.
The devils who oppose Grayfia's family could be the main antagonists. They might see Grayfia's brother - in - law as a weak link or a potential threat to their power. So they would try to get rid of him or manipulate him for their own gains.
The Hidden Leaf Village elders could be main antagonists. If Naruto turns dark because he feels betrayed by the village, they would be the ones representing the establishment he is against. Their conservative and sometimes self - serving ways could be the catalyst for Naruto's transformation, and then they would be the ones trying to stop him as he becomes a threat to their power and the village's traditional order.