One plot idea could be that the OC is a new villain in Gotham. Harley Quinn becomes yandere for the OC because of their unique style of chaos. She starts to stalk the OC, leaving little gifts that are both disturbing and endearing, like a dead bird with a love note.
For Harley, her yandere trait could develop as a result of her constantly being betrayed in her past relationships. When she meets the OC, she sees them as someone she can finally have complete control over, so she becomes overprotective and possessive.
One idea could be that the OC is a new hero in the DC universe. The yandere Enchantress becomes obsessed with the OC because of their unique powers. She starts to manipulate situations to be around the OC more, like causing villains to attack near where the OC is so she can 'help' and get closer to them.
Another theme is friendship. Despite their differences, Harley and the OC form a bond. It could start as a reluctant partnership but develop into a real friendship over time. Like in some fanfictions where they go through tough situations together and learn to trust each other.
One idea could be that the OC is a new villain in Gotham and Harley Quinn takes an immediate liking to their chaotic style. They team up to pull off a heist on one of Gotham's richest, with Harley's unpredictable nature and the OC's unique skills making for an exciting adventure.
The Fem OC could be a reformed hero who is trying to stop Harley Quinn from her villainous ways. But as they interact more, they start to understand each other's perspectives and end up teaming up against a bigger threat in Gotham. This would involve a lot of character development for both of them as they learn from each other.
One possible title could be 'The Adventures of Harley Quinn and Her Fem OC Ally'.
One idea could be that the yandere female villain discovers the OC has some sort of power or knowledge that she wants for herself. So she starts to stalk the OC in the DC universe. Maybe the OC is a new hero or just an ordinary person with a connection to a powerful artifact. The yandere's actions could lead to all sorts of chaos as she tries to get closer to the OC, and the OC has to figure out how to deal with this obsessive villain while also navigating the dangerous DC world.
Power dynamics is another theme. Given Harley Quinn's complex relationship with power, especially in relation to the Joker, the male oc can bring a new element to this. Maybe he has his own power struggle within the DC underworld, and his relationship with Harley Quinn either complicates or simplifies that struggle. It could also involve themes of loyalty and betrayal, as in the world of DC, alliances can be fickle.
Yes, there are many. You can find some on popular fanfiction websites like Archive of Our Own. Some explore Harley's complex relationship with Batman, often delving into her chaotic nature and how it interacts with Batman's sense of justice.
One great 'oc x Harley Quinn fanfiction' is 'Harley's New Ally'. In this story, the original character (oc) is a vigilante who crosses paths with Harley Quinn. They start off as enemies but gradually develop an understanding. The author does a great job of capturing Harley's complex personality and how the oc challenges her views. It has some really interesting action scenes and character interactions that make it a fun read.