Even some of the gods could turn against Percy. Maybe Zeus, fearing Percy's power as the son of destruction, decides that he is too dangerous to be left alive. This would put Percy in a very difficult situation where he has to fight not only the god of the sky but also deal with his own identity as a demigod.
The Titans could still be a major threat. They might see Percy's new - found power as a way to finally overthrow the gods and use him as a weapon. Kronos, if he were to somehow be resurrected again, would be a formidable antagonist.
Some new, made - up villains could also be introduced. For example, a group of powerful dark demigods who are jealous of Percy's power and want to steal it for themselves. They could have their own motives for causing destruction and may try to frame Percy for their evil deeds.
Obviously, the Primordial of Destruction itself would be a major antagonist. It's a powerful and chaotic force that wants to bring about destruction. But also, there could be some demigods who are influenced by the Primordial's power and turn against Percy. They might be jealous of his power or simply be corrupted by the allure of destruction. Another possible antagonist could be an ancient cult that worships the Primordial of Destruction and is trying to bring it back to full power. They would do anything to stop Percy from interfering with their plans.
Gaea herself would obviously be a main antagonist. She has the power to manipulate the earth and all its forces against Percy. Her children who are fully committed to her cause could also be major antagonists. They might have powers related to the earth and be very difficult for Percy to defeat.
The main antagonists could be the Titans. They are powerful enemies in the Percy Jackson universe already. Now that Percy has Superman - like powers, they might see him as an even greater threat to their plans of overthrowing the gods. So, they would do everything in their power to stop him.
The Titans could be great antagonists. Since they once rebelled against the gods, they might see Percy, as the son of Selene, as a threat to their plans of regaining power. They could try to capture him to use his connection to Selene for their own dark purposes. For example, Kronos might want to use Percy's powers to control the moon and disrupt the balance of the world further.
The Titans who don't want Rhea to gain more power through Percy could be antagonists. Kronos, for example, might see Percy as a threat to his own plans for domination.
Another option could be some power - hungry demigods. They might not like the idea of Percy, as the son of Themis, having the potential to bring real justice to the demigod world. They could try to undermine him at every turn, creating all sorts of obstacles for him in his quests.
The Titans who were once allied with Atlas could be antagonists. They might see Percy as a threat since he is Atlas's son and could potentially stand in their way of regaining power. Kronos' followers who still hold grudges against the Olympians and by extension, Percy, could also be main antagonists.
The Giants could be great antagonists. Since Percy is now connected to Juno, they might see him as a key figure to target in their war against the gods. They could try to use his new identity against him and the other demigods.
The Titans could be great antagonists. Since they often oppose the gods, they might see Percy as a threat, especially if he is the son of Leto. Kronos, for example, could try to stop Percy from fulfilling any prophecies related to Leto or the gods in general.
The Titans could still be a major threat. For example, Kronos' followers who might be trying to rise again and regain power. They could target the children of Athena because of their wisdom and strategic abilities, seeing them as a big obstacle to their plans.