Maybe some corrupt officials within the prison system itself. They oppose Naruto's more humane and reform - focused approach to prison management. They might try to undermine him at every turn, for example, by cutting off resources or spreading false rumors about him among the prisoners.
There could be a powerful and mysterious criminal mastermind who is locked up in the prison. He manipulates other prisoners from the shadows to cause chaos and try to escape. He sees Naruto as a major obstacle in his path to freedom and uses his intelligence and influence to create problems for Naruto.
The Sound Ninjas could be great antagonists. They could use their own unique parkour - like skills to try and stop Naruto. They might be chasing him through the forest, and Naruto has to use his parkour skills to outmaneuver them.
Maybe a group of dark - type Pokémon that have banded together and are trying to overthrow Arceus. They view Naruto as an easy target at first, but quickly realize he is a formidable opponent with his ninja skills and new Pokémon - related powers. They would constantly try to undermine Naruto and his efforts to protect the Pokémon world.
The Hidden Leaf Village elders could be main antagonists. If Naruto turns dark because he feels betrayed by the village, they would be the ones representing the establishment he is against. Their conservative and sometimes self - serving ways could be the catalyst for Naruto's transformation, and then they would be the ones trying to stop him as he becomes a threat to their power and the village's traditional order.
It could be the traditional enemies from Naruto's world, like the Akatsuki. They might see the union of Naruto and Rias and their unborn child as a threat to their plans for world domination. They could try to kidnap Rias to use her as a bargaining chip against Naruto or to study the unique nature of their child.
The village elders could be antagonists. They might see Naruto as a threat due to his devil - like origin and try to eliminate him. They fear that his powers could bring chaos to the village.
One likely main antagonist could be a powerful demon lord who is trying to break through the barriers between the spirit world and the human world. This demon lord would be a major threat to Naruto and his harem, and they would have to use all their combined skills to stop it.
The main antagonists could be the traditionalist nobles who oppose Naruto's new and inclusive ways of ruling. They might be afraid of losing their power and privilege.
It could be Orochimaru. Even though he was defeated before, he might come back with a new plan. Maybe he wants to use Naruto and Naruko's family for some dark experiment, like trying to extract the unique chakra combination that their family might have.
One antagonist could be Orochimaru from Naruto's world. He could be interested in the power of Quirks in Deku's world and try to capture Deku to study his power. He would be a formidable foe as he is a master of ninjutsu and has a lot of devious plans.
It could be rogue ninja groups that oppose Naruto's new way of ruling. These groups might believe that Naruto is trying to take away their freedom and the traditional ways of the ninja world. They could try to undermine his empire by causing chaos and attacking his infrastructure.