With his friends like Charles, Jake's ADHD could lead to some hilarious and heartwarming moments. Charles might be very understanding and even use his knowledge of Jake's ADHD to help him out. For example, when Jake forgets something important, Charles is there to remind him, strengthening their friendship.
His ADHD might make his relationships more interesting. For instance, with Amy, she could initially be frustrated by his scattered thinking but later come to appreciate how his ADHD - fueled creativity helps in solving cases. It could add a layer of complexity and growth to their relationship.
One interesting plot could be Jake's journey in dealing with his ADHD while on a particularly complex case. His ADHD might make him notice details others miss, but also cause distractions. For example, he could be chasing a suspect and his ADHD makes him suddenly remember a small clue he saw earlier at the crime scene that helps solve the case.
If Naruto has a physical disability like a broken arm that doesn't heal properly in fanfiction, his friends like Sasuke and Sakura would need to step in and help him more. Sasuke might be more protective, which could change their dynamic from a competitive one to a more collaborative one. Sakura could use her medical skills to try and find a way to heal him, which would bring them closer. His relationship with his teachers, like Kakashi, would also change as they'd have to adjust their training methods.
His relationship with Naruto would become more complicated. Naruto might be torn between believing in Sasuke's innocence and following the village's decision. Sakura would be deeply affected too. She might be in disbelief and try to find a way to get Sasuke reinstated.
In certain fanfictions, the izuku system is a secret. This secrecy can strain his relationships as he has to constantly lie or be evasive about his sudden improvements. But when the truth comes out, it can either lead to a huge rift or a deeper understanding among his friends, depending on how the writer chooses to portray it.
His relationship with his sensei, like Kakashi, could become more complex. Kakashi would feel guilty for not being able to protect Naruto from the experiments. And Naruto might start to question Kakashi's ability to keep him safe. This could lead to a strain in their relationship at first, but later they could grow closer as Kakashi helps Naruto recover from the trauma of the experiments.
Enemies would definitely be more cautious around Naruto. Those who once underestimated him would now fear his golden chakra. This could lead to some enemies trying to find weaknesses in it. Meanwhile, Naruto's new power might also attract the attention of mysterious characters who want to guide him in using it, which could cause some friction with his existing relationships as he has to decide who to trust.
His friends would be extremely worried. Sakura, for instance, would likely try to use her medical skills to help him and also try to figure out why he's doing it. She might be angry at first for him harming himself but then become very concerned. His relationship with Sasuke could also change. Sasuke might see Naruto's self - harm as a sign of weakness or, on the other hand, it could make him more empathetic towards Naruto as he has his own inner demons.
His skill with the bow might make him more respected. Other characters would see him as a valuable asset in battles or hunts. They might rely on him more, which could strengthen their bonds.
His friends usually find it quite amusing. Ron and Hermione might at first be a bit exasperated but then they end up enjoying the chaos. For example, when Harry pranks the Slytherins, Ron might be initially worried about getting in trouble but then laugh when they see the Slytherins' reactions. Hermione, on the other hand, might scold Harry but secretly be entertained.
When Izuku has a mythical quirk in fanfiction, say a power to transform into mythical creatures, it can change how others perceive him. His classmates might be in awe or a bit scared at first. But as time goes on, they would learn to work with his new abilities. His relationship with his teachers also changes as they have to figure out how to train him to control this unique quirk.