Who could be the main antagonist in a Harry Potter Potter Manor fanfiction?

Voldemort could still be the main antagonist. Even if Demetri has some sort of connection or change in the fanfiction, Voldemort's overarching evil plans would still be a major threat to both Harry and Demetri, especially if Demetri tries to deviate from the Death Eaters' path.

The minotaur itself could be the main antagonist. It's a powerful and dangerous creature, and if it's been set loose in Hogwarts or is guarding something that Harry needs, it would be a major obstacle for him to overcome.

The main antagonist could be a dark wizard who has made the graveyard his lair. He uses the dark energy from the tombstones and the restless spirits there to power his dark magic. Harry stumbles upon this wizard's activities and has to stop him.

A new dark wizard or witch could be the main antagonist. This character, jealous of Harry's fame and power, creates a situation where Harry is framed for a heinous crime. They then ensure his arrest so that they can take over the role of the 'chosen one' in the eyes of the wizarding public and start spreading their own brand of dark magic.

It could be Malfoy. He might make fun of Harry for wearing a dress and try to use it to humiliate him in front of the whole school, which would then lead to a conflict between them that goes beyond the usual rivalry.

Perhaps a new dark wizard or witch who has infiltrated the Ministry of Magic and made sure Harry was sent to Azkaban. This antagonist could be working towards a bigger plan to take over the wizarding world and sees Harry as a major threat even when he's locked up.

Maybe a dark wizard who has an interest in Harry's newfound inheritance. This antagonist could want to steal his powers or use him for their own evil purposes. They might see Harry as a key to unlocking some ancient and powerful magic that they've been seeking.

Perhaps a group of dark wizards who think that by disrupting time, they can bring back the dark ages of wizardry. They target the Timekeeper as the only one who can stop them. They use dark spells and curses to try and stop the Timekeeper from fixing the time - related problems they create.

It could be Voldemort. He might see Harry's new waterbending ability as a threat and try to find a way to counter it. Maybe he would seek out dark magic related to fire to oppose Harry's water powers.

It could be a dark wizard who has the power to control bats and uses them for evil purposes. He might be trying to take over Hogwarts using his bat minions.