Another possibility is that an existing character is corrupted by the allure of the Eye of the Moon Plan and becomes the main antagonist. For instance, a character who was once a friend or ally might be swayed by the power that the plan could potentially offer. This character's transformation into an antagonist could be a central part of the fanfiction's plot, with the other characters having to deal with the betrayal and the new threat that this former friend now poses in relation to the Eye of the Moon Plan.
Perhaps a new character is introduced as the main antagonist. This character could be from a hidden clan that has its own motives regarding the Eye of the Moon Plan. They might see it as a way to gain ultimate power and control over the ninja world. They could manipulate other characters and events to further their own goals related to the plan. For example, they could trick Naruto or Sasuke into believing they are on their side, while actually working against them in the context of the Eye of the Moon Plan.
It could be a new, mysterious ninja from a far - off land. This ninja might have a vendetta against Naruto for some reason, like Naruto interfering in their plans before. They could be extremely powerful and use some sort of dark jutsu to target Naruto's eye specifically.
Well, one possible plot development could be the exploration of different characters' reactions to the Eye of the Moon Plan. Maybe some characters who were previously on the sidelines become key players in either supporting or opposing it.
It could be a long - lost moon - dwelling ninja clan that has a grudge against the Leaf Village. They see Naruto as a threat to their plans on the moon's dark side.
It could be a rogue ninja from a hidden village that has a grudge against Naruto. This ninja might have a special jutsu that specifically targets Naruto's left eye during a fight, causing him to lose it.
It could be an old enemy like Kronos. Kronos is extremely powerful and cruel. He might target Percy's eye as a way to weaken him both physically and mentally. By taking away Percy's eye, Kronos hopes to make Percy less effective in battle and to shatter his confidence, which is crucial for leading the demigods against him.
One interesting concept could be alternative ways to achieve the Moon Eye Plan. Maybe a character finds a way to modify the plan to bring about a different kind of peace. For example, instead of putting everyone in an illusionary world, they use the power of the plan to make people more empathetic in the real world.
A rogue Uchiha who has lost the use of one of his Sharingan eyes due to a failed experiment. He becomes jealous of the protagonist who has one working Sharingan eye and tries to take it for himself. He might use his remaining Sharingan powers in cruel and unexpected ways to try and defeat the protagonist.
It could be a dark sorcerer who wants to steal the power of the moon for his own evil purposes. He sees Mune as the only obstacle in his way, so he tries to undermine Mune at every turn.
Maybe a corrupted version of one of the Sailor Scouts. She could be jealous of Naruto's attention towards the other Scouts in the harem. So, she makes a deal with a dark force from Naruto's world, like a powerful Orochimaru - like character. This combined power of dark jutsu and a twisted Sailor power would create a very interesting and complex main antagonist for this crossover fanfiction.
It often expands on the characters' backstories related to the Moon Eye Plan. For instance, we might learn more about Madara's true intentions and what led him to create such a drastic plan. This can give more depth to his character.