As for Kakashi, he would be in a difficult position. He has mentored Naruto and also has a strong loyalty to Konoha. He might try to understand Naruto's reasons while also having to deal with the village's reaction. Their relationship could become strained as Kakashi tries to balance his duties to the village and his connection with Naruto.
At first, Naruto is likely to be heartbroken. Konoha has been his home, and he has always longed for acceptance from the villagers. So being abandoned would be a huge blow to him.
Many relationships would be affected. For example, Sasuke's story would take a different turn. He might not have the same motivation to return to Konoha if Naruto is not there. Also, Naruto's other friends like Sakura would be devastated and might set out on a journey to find him. The power dynamics in the ninja world would shift as well, with other villages possibly seeing Konoha as weaker without Naruto.
His relationship with Sakura could also change. Sakura might be both amazed and a bit worried about Naruto's new power. She could see it as a great asset in protecting the village but also be concerned about Naruto getting in over his head. This could lead to her being more protective of Naruto in a different way than before, perhaps trying to study more about psychokinesis to help him control it better.
Well, their friends in Konoha would be really sad. For Naruto, his friends like Sakura and Shikamaru would feel betrayed at first. They might not understand why he left without saying much. But later, they might start to suspect that there are deeper reasons and some of them might even try to find out the truth and support Naruto from afar.
With the villagers of Konoha, Naruto was once seen as a hero. But his leaving could cause mixed feelings. Some might see it as a betrayal, while others might respect his choice. Fem Sasuke was always an enigma in Konoha. Her leaving might be seen as expected by some, but for those who hoped she would fully integrate into the village, it would be disappointing. And as they journey outside Konoha, they will meet new characters, and their relationships with them will be based on their new identities as outcasts from Konoha.
Well, if Naruto has no emotions in the fanfic, his relationships would become very strange. For example, his bond with Sasuke might not be as intense. Normally, their relationship is full of passion, rivalry, and a deep sense of friendship. But without emotions, Naruto might just see Sasuke as another ninja, not someone he has a strong emotional connection with. His interactions with Sakura would also be different. Instead of having his unrequited love for her, he'd be indifferent, which would change the whole dynamic of their trio.
This fanfiction might make Naruto more of a loner. In the original, he was always surrounded by friends and the support of the village. Abandoning Konoha would force him to rely only on himself and his own powers. His character could become more cynical as he distances himself from the place he once called home.
With his friends like Sakura, their relationship could shift. They might bond over more 'feminine' experiences if Naruto has a feminine body. For example, they could share stories about clothing or certain social situations that are more common among female characters. It could also lead to some jealousy or new - found respect between them.
It could change his relationship with Sakura. Sakura might be a bit wary of Naruto at first because of the unknown effects of absorbing Zetsu. But as she sees that Naruto is still the same person at heart, she would gradually accept him again. With Kakashi, he might be more cautious and keep a closer eye on Naruto to make sure he doesn't lose control.
One possible reason could be fear. Naruto has the Nine - Tails within him, and some in Konoha might be too afraid of its power getting out of control. They may not fully trust Naruto to keep it in check.