Well, it could be that Hinata might break Naruto's heart by choosing someone else over him. Maybe she realizes she has feelings for another character, like Sasuke perhaps. This would be a huge shock to Naruto as he has always seen Hinata as a special person in his life.
In this fanfiction scenario, Hinata could break Naruto's heart because of her family's wishes. Her family might not approve of Naruto for some reason, like his past as an outcast or his dangerous ninja lifestyle. Hinata, being loyal to her family, decides to end things with Naruto, leaving him heartbroken.
Well, it could be that Hinata starts to ignore Naruto for some reason, like she falls in love with someone else. Maybe she gets influenced by some external force or false information that makes her believe Naruto isn't good for her. This sudden change in her behavior towards Naruto would break his heart as he might have deep feelings for her.
One consequence could be that Hinata tries to move on but struggles a great deal. She might have a hard time opening up to anyone else in the future. Her self - confidence could also take a big hit. Since she put so much of herself into her feelings for Naruto, having her heart broken could make her question her own worth. Maybe she starts to think that if Naruto didn't love her, then no one will. This could lead to her being more reserved and less likely to take risks in relationships or in other aspects of her life.
It could be that Hinata publicly humiliates Naruto. She might expose some of his deepest insecurities in front of the whole village. Since Naruto has always been striving for the village's acceptance, this betrayal from Hinata, who he loves, would be a huge blow to his heart.
In some fanfictions, Naruto could break Hinata's heart by choosing another girl over her. For example, if he decides to be with Sakura instead. Hinata has always had deep feelings for Naruto, and seeing him with someone else would shatter her heart. It could also be that Naruto ignores Hinata's sacrifices for him and takes her for granted, which slowly breaks her heart as she realizes he doesn't value her as much as she thought.
In this fanfiction, it could be that Akeno chooses someone else over Naruto. She might publicly reject Naruto in a really humiliating way, like in front of all their friends and allies. This would definitely break Naruto's heart as he is a character who values relationships deeply. He would be heartbroken not just because of the loss of a romantic interest but also because of the feeling of being publicly shamed and rejected.
Well, it could be that Anko does something really cruel like betraying Naruto's trust. Maybe she lies to him about something he deeply cares about, like his dreams of becoming Hokage. And this lie shatters his hopes and thus breaks his heart.
Perhaps Ino lies to Naruto about something really important, like leading him on with false hopes of a relationship. She could make him think she has feelings for him, but then suddenly reveals it was all a joke or part of a mission. This would shatter Naruto's heart because he's so sincere in his emotions. He'd feel used and betrayed.
Well, perhaps Erza might reject Naruto's feelings in a cruel way. Maybe she tells him she loves someone else, like Jellal. This would break Naruto's heart as he is used to being persistent in love, like his feelings for Sakura in the original series.
At first, Naruto would be in denial. He has always seen Hinata as someone who supported him. But as the reality sinks in, he would be heartbroken. He might try to find ways to win her back, showing her how much he truly cares. He'd also be very sad and might even lose some of his usual cheerfulness for a long time.
Maybe it's a jealous rival of Naruto who wants Hinata for himself. He manipulates situations in such a way that Hinata ends up hurting Naruto. For example, he could stage events to make Hinata think Naruto has betrayed her trust.