A group of rogue ninjas who have made the island their base could be antagonists. They might see Naruto as a threat to their operations on the island.
The island itself could be a sort of antagonist in a way. If it has a will of its own, it could try to keep Naruto trapped there. For example, the island could create illusions or natural disasters to stop Naruto from leaving. Another potential antagonist could be a clan that has been exiled to the island and they don't want Naruto to bring the outside world's attention to them, so they try to stop him by any means necessary.
Maybe there is a powerful and corrupted chakra - based creature on the island. It has been awakened by Naruto's arrival and now wants to consume his chakra. This creature could be a very dangerous antagonist as it has unique abilities based on the island's own chakra flow. Also, there could be a traitor among the people Naruto meets on the island. This person could be working with an outside force against Naruto, causing all sorts of trouble for him as he tries to figure out what's going on and how to get off the island.
A group of traditionalists in Akeno's world could be antagonists. They might not approve of the idea of a harem or of an outsider like Naruto having so much influence. So they could try to break up the harem and drive Naruto out of their world by using political means, like spreading false rumors about Naruto and his friends.
Perhaps a powerful and corrupt merchant group could be the antagonists. They are secretly trying to take over the village's economy and resources. They use bribes and blackmail to get their way. The Sixth Hokage discovers their plot and has to stop them without causing too much chaos in the village's economic system. They may also have some ninja mercenaries working for them.
One potential antagonist could be a rogue ninja who also has aerokinesis but uses it for evil. He might be jealous of Naruto's natural talent and try to undermine him at every turn. Another could be a powerful sorcerer from a far - off land who has come to the Naruto universe specifically to find someone with aerokinesis to either steal their power or use them as a tool. There could also be a group of anti - ninja who see Naruto's new power as a threat to their plans of overthrowing the ninja system and they try to eliminate him.
Hinata is a likely candidate. She has always had deep feelings for Naruto. On the island, her gentle and caring nature would make her an important part of the harem. Sakura could also be there. Despite her initial feelings for Sasuke, being stranded on an island with Naruto might make her see him in a new light.
It could be a group of rogue ninjas who also ended up on the island. They might be after some valuable resource on the island and see Naruto and Tsunade as obstacles.
Another antagonist could be a group within the ninja village itself. Maybe they fear the changes that the child of prophecy might bring. They could be the more conservative elements who don't want to see new ideas or powers emerging. They might try to undermine the child's training or spread false rumors about them. For example, they could claim that the child is a danger to the village, turning public opinion against the child.
Perhaps Orochimaru could still be an antagonist. In this fanfiction, he might be jealous of Naruto's new god - like gaming powers and try to steal them for his own experiments.
There could be a jealous fellow ninja from within the village who feels that Naruto is getting too much attention for his blade - mastery. This ninja could turn against Naruto and become an antagonist, perhaps even teaming up with external forces. Also, an ancient evil entity that was sealed away long ago might be awakened by the power of Naruto's blade and seek to destroy him and the village to regain its freedom.
There could be new antagonists created specifically for this fanfiction. Maybe some other ninja from a far - off land who are jealous of Naruto's power. They could come to the Hidden Leaf Village to challenge Naruto and steal his speed - related secrets.
One potential antagonist could be Orochimaru. He might be interested in Naruto's Mokuton powers for his own evil experiments. He could try to capture Naruto to study how he awakened the Mokuton and use that knowledge for his own gain.