One plot idea could be that Sakura, with her medical ninjutsu skills, ends up in the Inuyasha world and helps to heal some of the injured villagers. Her knowledge of herbs and healing techniques could be a new concept in that world. Another idea is that she gets involved in the search for the Shikon Jewel. Since she has combat skills from her ninja training, she could assist Inuyasha and his group in fighting off demons who also want the jewel. Maybe she could even form a friendship with Kagome, and they could learn from each other's strengths.
A possible plot could be that Sakura accidentally crosses over during a strange ninja mission gone wrong. In the Inuyasha world, she is mistaken for a powerful priestess at first because of her chakra control. This leads to her being dragged into the conflict between Inuyasha and some powerful demons. As she tries to find a way back to her own world, she discovers that there are some similarities between the two worlds in terms of energy manipulation. So she starts to study the spiritual powers in the Inuyasha world and uses her ninja knowledge to adapt and survive.
Well, she could be summoned to the Inuyasha world by a dark magic user who wants to use her power. Once there, she teams up with Inuyasha not by choice at first but because they both have a common enemy. Sakura's ability to analyze situations quickly and her combat skills would come in handy. Along the way, she might also teach some of the characters in the Inuyasha world about the concept of teamwork in a different way than they are used to, as she has experience from being part of a ninja team.
One idea could be that Sakura, with her medical ninjutsu skills, ends up in the Feudal era of Inuyasha. She could help treat the wounds of the villagers who are often attacked by demons. Inuyasha might be initially suspicious of her strange powers but gradually come to respect her as she proves her worth in battles and in healing the injured. For example, when Inuyasha gets seriously injured in a fight against a powerful demon, Sakura's medical skills could be the key to saving him, which would change his view of her.
One idea could be a crossover with the Harry Potter universe. Sakura could be a transfer student to Hogwarts, bringing her ninja skills and knowledge of chakra into the wizarding world. Maybe she'd be sorted into Gryffindor for her courage. Another idea is a crossover with the Avatar: The Last Airbender world. Sakura could learn bending techniques and use her medical skills to help in the fight against the Fire Nation. She might also form an interesting bond with Katara, sharing their knowledge of healing.
One idea could be that Sakura, with her medical ninja skills, ends up at Hogwarts as an exchange student. She might use her chakra control to enhance the potions class, for example, by being able to precisely measure and mix ingredients in a unique way. Another plot could involve Sakura getting involved in the fight against Voldemort. Her combat skills and ability to sense danger could be very useful in the wizarding world.
One plot idea could be that Sakura, while on a mission, stumbles upon Pein's base by accident. She tries to use her medical skills to heal some of the injured Akatsuki members there as a way to negotiate peace, which surprises Pein. Another could be a time - travel scenario where Sakura goes back in time and meets a younger Pein before he becomes the leader of the Akatsuki, and she tries to change his path. A third idea is that Pein captures Sakura to use her knowledge of medical ninjutsu for his own purposes, but Sakura gradually makes him see the value of life in a different way.
Maybe Tobirama discovers Sakura's chakra control abilities and decides to study her in order to improve his own understanding of chakra. This leads to a series of experiments and training sessions together, during which they develop a mutual respect for each other's skills and determination.
A more complex plot could be Sakura trying to bridge the gap between the Leaf Village and the Mist Village. As Mizukage, she initiates cultural exchange programs. This includes sharing medical knowledge from the Leaf and learning about the unique water - based ninjutsu of the Mist. Along the way, she faces opposition from traditionalists in both villages but manages to bring about positive change.
One interesting plot could be that Sakura, on a diplomatic mission to Suna, gets lost in the desert and is rescued by Gaara. This encounter leads to a series of exchanges where they both learn about each other's past traumas and how they've overcome them. Another idea is that they team up to fight a new common enemy that threatens both Konoha and Suna, during which they develop a deep respect for each other's skills.
Another plot could be that the tattoo is a mark from a past encounter with an ancient and powerful being. As she tries to uncover the meaning of the tattoo, she gets drawn into a dangerous adventure that involves secrets from the ninja world's history.
One idea could be that Sakura Haruno, as a doctor, discovers a new and rare disease in the ninja world. She has to race against time to find a cure while facing opposition from traditional medical views. Another plot could involve her treating a powerful enemy ninja who holds secrets that could change the balance of power in the shinobi world. And also, she might travel to different villages as a medical ambassador, sharing her advanced medical knowledge and making new friends and allies along the way.
One idea could be that Sakura, as a princess, has to use her medical ninjutsu skills to save her kingdom from a mysterious plague. Another could be her having to navigate through political intrigue in the court while also trying to maintain her relationships with her friends. Maybe she discovers a hidden power within herself that is related to her princess lineage and uses it to protect her people from an invading force.