Perhaps a jealous classmate who discovers Artemis's connection to the fairy world. This classmate wants to use that knowledge to gain power and popularity, so they start causing trouble for Artemis and his friends, trying to expose them to the wrong people or get in the way of their fairy - related investigations.
A power - hungry fairy could be the main antagonist. This fairy might see Artemis as an upstart and a threat to their own position in the fairy hierarchy. They could try to undermine Artemis at every turn, setting up traps and spreading false rumors about him in the fairy world.
It could be a new demigod who has turned to the dark side. Jealous of Percy's popularity and Artemis' power, this demigod could try to create chaos in the high school and turn students against them.
Loki could be a great main antagonist. He could be the mischievous student who's always causing trouble for the Avengers. He might use his magic to play pranks on them or steal their homework to make them look bad in front of the teachers.
It could be a jealous classmate. Maybe someone who has a crush on Armin and sees Annie as a threat to their relationship. This person could try to spread rumors about Annie to make Armin stay away from her.
Perhaps a strict teacher who doesn't like Naruto's unorthodox ways and Anko's rebellious attitude. The teacher might try to split them up and prevent them from participating in school activities together. For example, if they want to enter a school competition as a team, the teacher could create obstacles.
Perhaps Orochimaru from Naruto could be the main antagonist. He's always seeking more power, and in this fanfic, he might see the powers in 'The God of High School' as a means to achieve ultimate power. He could try to manipulate the events of the 'The God of High School' tournaments to his advantage, all while causing chaos in Naruto's world as well.
Gary could be a main antagonist. He might be jealous of Ash's popularity at school and constantly try to undermine him in Pokemon battles and in front of their classmates.
One idea could be Artemis starting a secret club at high school to study ancient languages and artifacts, leading to unexpected adventures. Maybe he discovers a hidden code in a school text that links to a mythical treasure.
A strict teacher could be an antagonist. Maybe this teacher has old - fashioned views and doesn't like Percy's unorthodox ways or Artemis's independent streak. The teacher could constantly give them detention or try to stop them from participating in certain school events that are important for the plot.
A great main antagonist could be a powerful Titan who has somehow escaped from Tartarus and is seeking revenge on the gods. He could target the Hunters of Artemis because they are loyal to Artemis, a goddess he has a grudge against, and Percy because of his connection to Poseidon.