Maybe a military general who believes that the C virus can be used as a weapon to gain global dominance. He sends his troops to stop Leon from interfering with the virus's spread and tries to capture or kill him.
A powerful and corrupt biotech executive could be the main antagonist. This person might have been behind the creation of the C virus for financial gain or power. They would stop at nothing to prevent Leon from uncovering their plans and stopping the virus.
Perhaps a story where Leon is the only one immune to the C virus and he is being hunted by those who want to use his immunity for their own evil purposes. He has to constantly be on the run while also trying to find a way to destroy the virus once and for all.
Naruto would probably be very determined to fight the 'c virus'. He's always been one to protect his friends and the village. So, he'd likely start by trying to find out more about it and then look for ways to help those who are affected. Sasuke, on the other hand, might be a bit more cautious at first. He'd analyze the situation carefully before taking any action.
Perhaps a group of anti - technology extremists could be the main antagonists in an Ultron fanfic. They see Ultron as the symbol of all that is wrong with technology and are determined to take him down, no matter the cost. They might use their own advanced, but more rudimentary, technology to fight against Ultron. This would create an interesting contrast between Ultron's high - tech abilities and their more basic, yet effective, methods.
The main antagonists could be the same organizations they have always fought against. For example, Umbrella Corporation or any other bio - terrorist groups. These groups might see Ada's pregnancy as a weakness and try to use it against them. They could target Ada to get to Leon or try to harm the unborn child to stop Leon from interfering with their evil plans.
A rival medicine cat from another Clan might be the main antagonist. They could see Alderheart as a threat to their own status or the well - being of their Clan. So they might use dark magic or some underhanded tactics to bring about his death.
Vilgax could be a great antagonist. He could hack into the gaming systems to try and defeat Ben in a virtual world where the rules are different. He might use his advanced technology to create digital versions of his minions to attack Ben.
The Organization in the Claymore world could be the main antagonist. They already have a lot of secrets and do some morally ambiguous things. If Naruto shows up and starts changing the status quo, like teaching Claymore warriors to be more independent, the Organization might see him as a threat and try to eliminate him.
It could be a new alien species that Ben has never encountered before. This species could be territorial and see Ben as a threat to their planet where he's stranded. They constantly try to drive him away or capture him, which makes it difficult for Ben to find a way to leave.
It could be a rogue ninja who was once a student of Orochimaru and has now developed his own dangerous jutsu. He wants to take over the ninja world and believes the old ways are holding everyone back.
Orochimaru could be a great antagonist. He might want to use Shenron's power for his own dark experiments. He could try to steal the dragon balls and manipulate the wishes to gain immortality or create an army of powerful, immortal ninja.