One possible plot twist could be that Orochimaru has a new jutsu that Naruto has to figure out quickly to save Sakura. Maybe it's a jutsu that messes with time, so Naruto has to break through different time loops to reach Sakura. Another could be that Orochimaru has an unexpected ally who tries to stop Naruto from rescuing Sakura. This ally could be someone from Naruto's past who has a grudge against him.
A plot twist could be that Orochimaru has implanted a part of his own soul into Sakura. Naruto then not only has to save Sakura from Orochimaru physically but also has to find a way to separate Orochimaru's soul fragment from her. This could lead to Naruto having to learn some ancient sealing techniques or seek help from unexpected sources like Kabuto who might have some knowledge about Orochimaru's experiments. Also, Sakura might gain some of Orochimaru's powers during this process, which makes her a danger to herself and Naruto at first, until Naruto can figure out how to control these powers within her.
A plot twist might be that Naruto and Sasuke discover a hidden agenda Orochimaru has that involves someone they care about deeply. For example, they find out he's planning to use Sakura as a sacrifice for some dark ritual. This would force them to quickly come up with a plan to rescue her and stop Orochimaru once and for all.
One possible plot twist could be that Sakura initially joins Orochimaru to gain more power to protect her friends, but she soon discovers that Orochimaru has ulterior motives regarding her unique chakra abilities. For example, he might want to use her as a vessel for some dark jutsu. Another twist could be that Orochimaru's henchmen start to develop loyalty towards Sakura instead of him because of her strong will and medical skills. This could lead to a split within Orochimaru's group, with some siding with Sakura and others remaining with Orochimaru.
One possible plot twist could be that Sakura, despite being raised by Orochimaru, retains her kind heart. She might secretly be working against Orochimaru's evil plans while pretending to be his loyal follower. For example, she could be sabotaging his experiments or passing information to the Hidden Leaf Village.
One possible plot twist could be that Sakura has been secretly training a new jutsu and uses it to outwit Orochimaru at the last moment. For example, she might have developed a genjutsu that can counter Orochimaru's mind - control techniques. Another twist could be that Naruto and Sasuke arrive just in time, but instead of a straightforward rescue, they find that Sakura has made a deal with Orochimaru in order to gain some powerful knowledge. This could lead to a rift between her and her teammates.
One possible plot twist could be that Orochimaru was actually being controlled by a greater evil, and Naruto has to not only save Hinata but also deal with this hidden threat. Maybe Orochimaru was forced to target Hinata to draw Naruto out for this other entity's purposes.
One possible plot twist could be that Naruto's 'godlike' powers are not his own but are the result of some ancient curse placed on Orochimaru that backfires. For example, Orochimaru was trying to gain ultimate power and in the process, he unknowingly transferred a powerful and uncontrollable energy to Naruto. So when Naruto kills Orochimaru, it's like the curse has completed its cycle. Another aspect could be the emotional turmoil Naruto goes through. Even though he has to kill Orochimaru for the greater good, it still weighs on his conscience because Naruto is a character who values all life. He might struggle with the idea that he had to take a life, even if it was someone as evil as Orochimaru.
Well, perhaps in the fanfiction, Naruto kills Orochimaru and the Akatsuki, but it turns out that Orochimaru had a failsafe. His death triggers a powerful curse that starts to affect Naruto and the Hidden Leaf Village. Naruto then has to find a way to break this curse while also dealing with the remaining threats that were associated with the Akatsuki. It could be a race against time to save the village and himself.
Well, in a Good Orochimaru Adopts Naruto fanfiction, the plot could take an interesting turn when Orochimaru tries to train Naruto. Since Orochimaru has such different and often dark jutsu, Naruto might struggle to adapt. But this could lead to Naruto creating his own unique style of combat that combines his Uzumaki resilience with some of Orochimaru's knowledge. And then there's the matter of how the rest of the village reacts. They might be very suspicious of Orochimaru's intentions and try to take Naruto away, which would create a whole new set of conflicts.
One possible plot twist could be that Orochimaru has an ulterior motive for training Sakura. Maybe he wants to use her new - found skills against Konoha in the future. Another could be that Sakura discovers a hidden power within herself during the training that Orochimaru wasn't expecting.
One possible plot twist could be that Naruto and Sasuke team up in an unexpected way to rescue Sakura. They might have to put aside their differences and use new jutsu or strategies. For example, Naruto could use his new Sage Mode abilities combined with Sasuke's Sharingan powers to outwit Orochimaru.