Aro from Twilight could also be a very powerful character in a combined universe. He has powerful mind - control abilities in the Twilight world. In the Game of Thrones universe, he could use these powers to manipulate the various lords and ladies, causing chaos or building his own power base. He could also use his vampiric strength and speed to defend himself against any threats, like the assassins in King's Landing or the wildlings.
Perhaps Daenerys Targaryen. If she were to somehow acquire vampire - like abilities, she would be an even more formidable force. Her dragons combined with vampire powers such as enhanced senses and immortality (in a sense) would make her a very powerful and dangerous character. She could use her newfound powers to rule Westeros more effectively or to take on new enemies.
Arya Stark combined with Inuyasha could be extremely powerful. Arya has her assassin skills and ability to change faces, and when combined with Inuyasha's demon powers and combat skills, she would be a force to be reckoned with. She could use Inuyasha's speed and strength to take on even the toughest opponents in both worlds.
However, Voldemort also has a claim to being the most powerful. His dark magic is extremely potent, and if he were to enter the Game of Thrones world, he could use fear and intimidation to gain power. He might even form alliances with some of the more ruthless characters in Westeros to achieve his goals.
It's hard to say for sure, but Ruby could be a very powerful character. Her speed and scythe skills are already formidable in the RWBY universe, and if she were to gain some of the combat knowledge from For Honor, like the strategic thinking of a For Honor general, she could be extremely powerful. She might be able to quickly analyze her opponents' fighting styles and counter them effectively.
Thor could also be very powerful. He has his Asgardian strength and his hammer (or Stormbreaker). If he were to also gain the ability to use magic like the wizards in Harry Potter, he could be near - invincible. He could call lightning while also casting spells. And his knowledge of different realms could give him an edge in any battles that span across the combined universes.
It could be Naruto himself. He has an enormous amount of Chakra and his ability to learn new techniques quickly. If he were to partner with a powerful Digimon like Omnimon, he would be nearly unstoppable. His ninja skills combined with Omnimon's power would make him a force to be reckoned with.
Gohan in his Ultimate form could also be a very powerful character in this combined fanfiction universe. He has incredible strength and intelligence in combat. But on the RWBY side, Ozpin has a lot of hidden power and knowledge. Still, when comparing their power levels, Gohan's physical strength and energy projection abilities are on a different scale. He could potentially take on even the toughest Grimm with ease. So, overall, Gohan might be among the most powerful in this crossover scenario.
It's hard to say for sure, but Master Chief could be a strong contender. His combat training and advanced armor give him an edge. However, Darth Sidious is extremely powerful with his dark side abilities. He could potentially manipulate Master Chief if he got the chance. But then again, the Forerunners from Halo have such advanced technology that they might be able to counter the Force -powers. So it really depends on how the story is written.
I think it could be a combined form of a character. For example, if Issei were to somehow gain the power of the Nine - Tailed Fox. He already has his Boosted Gear and his experience in battles in the Highschool DxD world. Adding the Nine - Tailed Fox's chakra would make him an extremely formidable opponent. He could use the fox's chakra to enhance his Sacred Gear even further, and his new form might have abilities that are a combination of both universes, like using the fox's tails as a weapon while also having the power of the Boosted Gear.
It could be Jon Snow. If he has a Stand in the fanfiction, combined with his already proven leadership skills and combat abilities, he would be a force to be reckoned with. His ability to come back from the dead might also be related to his Stand powers in some way, making him even more formidable.
It could be Akuma. He is extremely powerful in the Street Fighter universe with his dark Hadou powers. In a combined universe, his ability to manipulate dark energy could be enhanced by the magic in the Harry Potter world. He could potentially learn spells and use them in combination with his fighting skills, making him an almost unstoppable force.