It could be an old enemy of the gods who sees Percy as a threat because of the Curse of Achilles. Maybe a Titan who escaped from Tartarus and wants to use Percy's power for their own gain. If they can control Percy, they could have a powerful weapon against the gods.
A powerful Titan who was imprisoned long ago but whose power still lingers. This Titan could have some connection to Calypso's island and placed the curse as part of a long - term plan to gain freedom and revenge on the Olympians. They would be a formidable foe for Percy and Calypso to face.
It could be a new, powerful Titan that has emerged from the depths of Tartarus. This Titan might be seeking revenge on the demigods for imprisoning the other Titans and sees Hylla and Percy as the biggest threats.
A powerful sorcerer from another realm who uses assassins as tools. This sorcerer could see Percy as a threat to their plans of taking over the demigod world. They send their best assassins after Percy and also try to manipulate other demigods against him. They are extremely cunning and have a vast array of dark magic at their disposal.
The main antagonist could be a powerful Titan who wants to use Percy as a weapon to overthrow the Olympian gods. The Titan might see Percy's unique powers as a weapon as the perfect tool to gain ultimate power and reshape the world according to his own desires.
A great plot could involve Percy having to deal with the psychological impact of the Curse. He might start to feel overconfident and make mistakes. Then, his friends have to help him realize that the Curse is both a strength and a potential downfall. For example, he could be lured into a trap by an enemy who plays on his new - found sense of invulnerability.
There could also be antagonists. For instance, some old enemies of Percy might be drawn to him because of the Curse of Achilles. They might see it as a challenge or an opportunity to finally defeat him, and these antagonists would be important characters in driving the story forward.
A great antagonist could be a Titan who has a grudge against Zeus and sees Percy as an easy target to get back at him. For example, Atlas. He could try to use Percy to free himself from his burden again or trick Percy into doing something that would cause chaos among the gods. Another option is a powerful and vengeful demigod who feels that Percy, as the son of Zeus, has been given too much power and attention, so he wants to take Percy down.
A great main antagonist could be a powerful Titan who has somehow escaped from Tartarus and is seeking revenge on the gods. He could target the Hunters of Artemis because they are loyal to Artemis, a goddess he has a grudge against, and Percy because of his connection to Poseidon.
It could be one of Mars' old enemies, like a powerful Titan who has a grudge against Mars and sees Percy as a threat. Maybe this Titan wants to take over Mars and Percy stands in the way.
The main antagonist could also be an ancient and powerful spirit from the underworld that was sealed away long ago. Percy's presence as the son of Hades accidentally awakens this spirit. The spirit then starts to spread darkness and despair throughout the world of the demigods, and Percy has to find a way to stop it before it's too late.