One possible storyline could be that Sakura is outcast because she has developed a new and unorthodox ninja technique that others are afraid of. So she has to struggle alone, trying to prove its value.
Another storyline could be that Sakura's extreme intelligence in medical ninjutsu makes her stand out too much. The other ninjas feel inferior and start to shun her. She might then decide to open her own medical ninjutsu school away from the village to teach those who are willing to learn from her.
One possible storyline could be Sakura Haruno discovers a powerful artifact in the Naruto universe that gives her the abilities and guise of Catwoman. She then uses these new skills to protect Konoha from a new threat that the regular shinobi forces can't handle. For example, a group of thieves with unique jutsu that can steal people's chakra. Sakura, as Catwoman, uses her stealth and enhanced physical abilities to track them down.
One possible storyline could be that she sacrifices herself to save her friends in a battle against a powerful enemy. Maybe she uses all her chakra to protect the village from a massive attack and as a result, her life force fades away.
One possible storyline could be Sakura having to fend for herself on the streets. She might use her medical ninjutsu skills to help other homeless people in exchange for food or shelter. Another could be her trying to find a way back to her village while facing the hardships of being homeless, like dealing with thugs or harsh weather.
One possible storyline could be in a battle where she sacrifices herself to save her comrades. Maybe she's facing an overwhelmingly powerful enemy and uses a powerful jutsu that she knows will cost her life but will give her friends the chance to escape.
One possible storyline could be Sakura's journey to discover her true family roots. Maybe she finds a hidden diary or an old family heirloom that gives her some clues and she sets off on an adventure to find out more about her parents. Along the way, she could meet new friends or mentors who help her in her quest.
One possible storyline could be Sakura Haruno somehow getting transported to the One Piece world. She could use her medical skills, which are quite advanced in the Naruto universe, to help the Straw Hat crew. Maybe she teams up with Chopper to create new medical techniques or remedies on the ship.
One possible storyline could be that Sakura has to deal with the expectations and secrets related to her father's past. For example, if Yagura had some dark deeds in his past, Sakura might struggle to come to terms with it.
It could be some of her jealous peers. For example, those who are envious of Sakura's skills or her closeness to certain important characters in the Naruto universe. They might spread malicious gossip about her to make her an outcast.
One possible storyline could be Sakura's struggle to hide the abuse from her friends at school. She might constantly make excuses for her bruises or withdrawn behavior. For example, she could tell lies about getting injured during training when in fact it was her parents. Another could be her journey to find strength within herself to break free from the cycle of abuse. Maybe she starts to secretly train more vigorously to be able to stand up to her parents one day.
One possible storyline could be that Harry is wrongly accused of something at Hogwarts, which makes him an outcast. Ginny, being the strong - willed character she is, might be one of the few who still believe in Harry. She could secretly help him clear his name while also developing deeper feelings for him during this difficult time.