Voldemort could still be the main antagonist. Even if Harry is a 'child of magic' in a different way, Voldemort would still see him as a threat to his power and his vision of a pure - blood dominated wizarding world.
It could also be an old and powerful magical creature that has been awakened by some dark magic. This creature sees Harry as a threat to its existence because of his mastery of magic and decides to target him. For instance, a dragon that has been enchanted with dark magic to be more intelligent and malicious.
It could be a new dark wizard who is jealous of Harry Potter's fame and success. This dark wizard targets Harry's child, thinking that by causing trouble for the child, they can somehow diminish Harry's reputation in the wizarding world. He might try to frame the child for various dark magic incidents around Hogwarts.
It could be a criminal with a vendetta against Beckett. They might abduct the child to get back at her for putting their associates in jail in the past. This antagonist would be calculating and always one step ahead, making it a real challenge for Beckett to rescue the child.
It could be an archaeologist who has been corrupted by the power of an ancient artifact related to the mummy. This archaeologist wants to use the mummy's power for his own gain, like becoming immortal or ruling the world. He would be constantly trying to stop Harry from helping the mummy.
It could be a powerful dark wizard who has also gained some supervillain - like powers. This antagonist might be jealous of Harry's newfound superhero status and wants to destroy him.
It could be a distant relative of Voldemort who has been biding their time in the shadows. They might have a vendetta against the Potter family for what happened to Voldemort. This relative could be secretly gathering followers and planning to strike at the second child when they least expect it.
It could be a powerful dark wizard who has infiltrated the games under a false identity. This wizard might have a vendetta against Natsu or his guild and wants to disrupt the games and cause chaos.
It could be a jealous wizard who sees the relationship between Harry and the Lamia as a threat to his own power. He might try to disrupt the harmony in the circus and drive the Lamia away.
The main antagonist could be a powerful necromancer who combines the dark arts of Skyrim with some elements of Voldemort - like magic. He could be raising an army of the undead and causing chaos across Skyrim, which Harry has to stop.
It could be a new dark wizard who has a vendetta against Harry. This wizard might use a spell to stop Harry from eating, thinking it will weaken him before a final showdown. He could be someone who was once a follower of Voldemort and now wants to take his place and prove himself by getting rid of Harry.