Well, at first, most of Harry's Gryffindor friends would be taken aback. They have always had a certain animosity towards Slytherin. But as time goes on, if they see that the Slytherin Harry is betrothed to is kind - hearted and doesn't hold the same prejudices as some of the other Slytherins, they might start to come around. For instance, Seamus might start to joke around with the Slytherin, and Dean could start to include them in group activities. It would be a slow process of acceptance as they get to know the Slytherin better through Harry.
Harry would probably be deeply hurt. He has always considered Gryffindor his home in Hogwarts, so such a betrayal would be a huge blow to him. He might initially be in disbelief and try to find out the truth.
Hermione would probably be outraged. She would immediately start investigating the situation to find out the truth. She'd be convinced that there has been some sort of mistake or foul play. She might even go as far as to confront the teachers or the Gryffindor house leaders about it.
At first, Harry would be in disbelief. He would think it was some sort of joke or misunderstanding. But as the reality sets in, he would become a bit of a loner. He'd still have his sense of right and wrong, so he might continue to fight against the dark forces on his own, all the while hoping that his friends would come to their senses and realize they made a huge mistake in betraying him.
Hermione would probably be very cautious at first. She would be worried about the potential danger that Tom Riddle could pose, even as a child. But she might also see it as an opportunity to study the roots of dark magic and how to prevent someone from turning to the dark side.
He'd probably be devastated at first. Gryffindor has been his home at Hogwarts, and his friends are there. But he's also a resilient character. He might start to question the fairness of the banishment and try to prove his innocence. He could look for allies outside of Gryffindor, like Luna from Ravenclaw, who might believe in him.
He would probably be extremely hurt. Gryffindor was like his family at Hogwarts, so being exiled would be a huge blow. He might initially feel angry and betrayed.
In this fanfiction, a great plot twist could be that the Slytherin character has a hidden identity as a member of an ancient magic - protecting group. The betrothal to Harry is part of a bigger plan to unite the houses against a new, emerging dark force. As they come together, they face a lot of opposition from both sides, Gryffindor and Slytherin, but through their relationship, they start to bridge the gap between the two houses.
Well, Neville and Luna would have unique reactions. Luna would likely see it as a beautiful and magical event, perhaps even having some far - out theories about the baby's future abilities. Neville, being the kind - hearted person he is, would offer his help with any gardening or plant - related magic that could be useful during the pregnancy. Ginny might be a bit protective of Harry at first, but then warm up to Daphne as she realizes how much they love each other. Overall, their friends' reactions would be a blend of surprise, support, and a bit of worry in some cases.
I've also read 'Green and Red: A Slytherin - Gryffindor Love Story'. Here, Ginny is initially skeptical of Harry being in Slytherin. But as the story progresses, they discover they have more in common than they thought. The fanfic delves into their personal growth, their love for Quidditch which becomes a connection point, and how they overcome the house rivalries to be together.
Harry would likely be furious. He'd immediately start planning to rescue Hermione. He might try to gather evidence of the dark magic used to enslave her and take it to the teachers. Ron, on the other hand, would be impulsive. He'd probably want to storm into the Slytherin common room right away to free Hermione, without much of a plan.