A plotline might involve Naruto starting to act out in negative ways to get his parents' attention. He could start getting into trouble at school or in the village. Maybe he would start to explore his own powers in secret, away from his family, and discover some unique abilities that he then uses to show his parents what they've been missing. Also, there could be a plotline where Naruto tries to build a relationship with his sister in secret, hoping that through her, he can get closer to his parents.
In this fanfiction, a possible plotline is that Naruto becomes extremely independent and self - reliant due to the neglect. He focuses on building his own identity outside of his family. He might start a small business in the village or take on odd jobs. Another plotline could be that Naruto starts to investigate the reasons behind his parents' neglect. As he digs deeper, he discovers some long - hidden family secrets that change his perspective on his family situation. And there could also be a plotline where Naruto's sister realizes what's going on and tries to make amends between Naruto and their parents.