Sakura's reaction could be complex. At first, she may try to talk to Sasuke and plead with him to come back, showing her vulnerability. When she realizes it's futile, she could turn that pain into motivation. She might train harder than ever before, not just to show Sasuke what he's missing, but also to grow as a person. And she may develop a newfound sense of independence, realizing she doesn't need Sasuke to be a great ninja and a strong woman.
Sakura might be heartbroken. She's been in love with Sasuke for so long. She could initially go into denial, thinking it's just a temporary thing. Then she might get angry and vow to prove herself to Sasuke, perhaps by becoming an even stronger ninja.
Karin could be heartbroken. She might initially be angry and feel betrayed, lashing out at Sasuke for choosing Sakura over her.
In some fanfictions, Sakura may be determined to find Sasuke and bring him back. She could set out on her own journey, facing various challenges along the way, and growing both as a person and as a ninja in the process of trying to reunite with him.
She may initially be angry. Sakura is a proud and strong character. She could confront Sasuke and Ino, demanding an explanation. After that, she might decide to become even stronger, both in her ninja skills and her emotional resilience, to show Sasuke what he's missing.
She could be heartbroken. Sakura has always loved Sasuke deeply, so his leaving for Naruto would be a huge blow to her. She might initially be in denial, not believing that Sasuke would choose Naruto over her.
Naruto might initially be in denial. He's so used to having Sakura around and believing that they have a future together. So when she leaves for Sasuke, he might think it's just a temporary thing or that she's been influenced by something or someone. But as time passes and he realizes it's real, he would be deeply hurt. He might also start to question his own self - worth, thinking that he wasn't good enough for Sakura. And he might even try to win her back at first, but then slowly come to accept the situation and focus on his other responsibilities like being a ninja and protecting the village.
Another reaction could be that Sakura tries to follow Sasuke. She believes that she can change his mind or that she can be of help to him. She might leave her own responsibilities behind for a while to chase after him, thinking that their bond is strong enough to overcome whatever is making Sasuke leave.
She might be heartbroken. Sakura could initially be in shock and then fall into a deep sadness. She may blame herself for Naruto's leaving, thinking that she could have done something differently.
One possible reason in this fanfiction scenario could be that Sasuke feels a stronger connection to Karin on a spiritual or power - related level. Karin has unique abilities that might attract Sasuke more than Sakura's medical ninjutsu. Maybe he sees in Karin a kindred spirit in terms of their past traumas and the way they've had to fight to survive. Also, Karin has always been very devoted to Sasuke, and he might be drawn to that unwavering loyalty.
She may feel angry at first. Sakura is a strong - willed character. She might think that Naruto has made this decision without considering her feelings. In the fanfic, she could go on a rant about how he should have talked to her before making such a big decision.
In some fanfictions, Sakura's reaction could be more complex. She might be hurt not just physically but also emotionally. This could lead her to question her relationship with Sasuke and might cause her to make some big decisions, like whether to continue trying to reach out to him or to cut him off completely.