A plot twist could be that Naruto loses his ability to use chakra in the middle of a big battle against a powerful enemy. Sasuke, Sakura, and Kakashi then have to find a way to not only protect Naruto but also defeat the enemy without relying on Naruto's usual strength. This would force them to develop new strategies and explore different aspects of their own powers.
Imagine a fanfiction where Sakura, instead of being in love with Sasuke, has feelings for Naruto all along. This would completely change the love triangle aspect and lead to a lot of interesting interactions between the three main characters. It could also cause Sasuke to re - evaluate his relationship with his teammates.